Thieno[2,3-b]pyridine, 4-bromo- CAS No.: 1305208-22-3

📌Specification:

Appearance	off-white to white powder
Boiling Point	299.8 ± 20.0 °C (at 760 mmHg)
Density	1.748 ± 0.06 g/cm³
Flash Point	135.1 ± 21.8 °C
pKa	2.95 ± 0.30
Refraction Index	1.718
Vapor Pressure (25°C)	0.0 ± 0.6 mmHg
Storage	Recommended to store under low temperature, dry, and light-protected conditions.

🧩Application of Thieno[2,3-b]pyridine, 4-bromo- CAS No.: 1305208-22-3

1. Privileged Scaffold in Medicinal Chemistry

The thieno[2,3-b]pyridine ring system is an important fused heterocyclic scaffold that has attracted significant attention in medicinal chemistry and drug discovery. Combining the electronic properties of both thiophene and pyridine, it serves as a versatile building block for constructing biologically active molecules.

2. Key Synthetic Intermediate

The bromine atom at the 4-position makes this compound an ideal substrate for cross-coupling reactions, including:

Suzuki coupling (with boronic acids/esters to introduce aryl groups)

Stille coupling and Negishi coupling

Buchwald–Hartwig amination

Ullmann-type reactions

These reactions allow flexible introduction of various substituents at the 4-position, enabling rapid construction of thienopyridine derivative libraries for drug screening.

3. Biological Activity

Thieno[2,3-b]pyridine derivatives reported in the literature exhibit a range of biological activities:

Antitumor / antiproliferative activity

Antibacterial and antifungal activity

Anti-inflammatory activity

Kinase inhibition (e.g., tyrosine kinase targets)

Other potential pharmacological activities