Theaflavin CAS-no-4670-05-7_News

Description:
Theaflavin is a distinctive derivative of benzotropolones first extracted from black tea and has the antioxidant effects of radical scavenging and metal chelation functions. 
In addition, theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.
Theaflavin (20 and 50 μg/ml;2 h) inhibited oxidative stress injury to renal HK-2 tubular cell cells induced by calcium oxalate monohydrate (COM). 
Human umbilical vein endothelial cells (HUVECs) exposed Theaflavin(0-200μM;24 h) can alleviate apoptosis and cellular dysfunction induced by tert-butyl hydroperoxide (TBHP). 

Theaflavin (0-160μM;72 h) inhibited the proliferation of CNE2 cells, promoted apoptosis and upregulated the expression of caspase 3, caspase 9 and Bax, and decreased the level of Bcl-2.
Theaflavin(20、50、100 mg/kg; 14 days;i. g.)alleviated oxidative stress injury induced by CaOx nephrocalcinosis and crystal deposition in mice.
In a mouse model with renal ischemia/reperfusion injury (I/R), theaflavin pretreatment (20/50/80 mg/kg; 3 days;i. g.)significantly inhibited I/R-induced renal injury and cellular apoptosis.
It improved mitochondrial dysfunction by reducing mitochondrial damage and promoting mitochondrial membrane potential.
Definition ChEBI:
Theaflavin is a biflavonoid that is 3,4,5-trihydroxybenzocyclohepten-6-one which is substituted at positions 1 and 8 by (2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl groups. 
It is the main red pigment in black tea. It has a role as an antioxidant, a chelator, a plant metabolite, a radiation protective agent and an antibacterial agent. It is a polyphenol and a biflavonoid.

Application: 
Theaflavin is a polyphenolic compound found in black tea. Theaflavin derivatives show anti-HIV-1 activity by targeting gp41. Theaflavin is a potent inhibitor of amyloid-β (Aβ) and α-synuclein (αS) fibrillogenesis. 
Theaflavin also shows potent anti-tumor and and antoxidant activities. Theaflavin is active in the prevention of fatty liver and obesity, it can significantly reduce lipid accumulation, suppress fatty acid synthesis, and stimulate fatty acid oxidation. 
Theaflavin inhibits LPS-Induced IL-6, MCP-1, and ICAM-1 expression in bone marrow-derived macrophages through the blockade of NF-κB and MAPK signaling pathways; it also protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease.
Benefits:
Theaflavin is a polyphenolic flavonoid that has been found in black tea and has diverse biological activities, including antineoplastic, antioxidant, anticancer, anti-inflammatory, cholesterol lowering and antiviral properties.
Biological Activity:
Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.
                                             Product manager: Joy Wu                                                                Email address: Joy@coreychem.com