Fine Chemicals Insights | A Key Building Block for Organophosphorus Synthesis ✨
1. Product Overview
An important building block in organophosphorus chemistry, tert-Butylphosphorus Dichloride can be used in the synthesis of organophosphorus compounds and phosphine ligand-related intermediates, with applications in fine chemical and organic synthesis.
2. Basic Product Information
1) Product Name: tert-Butyldichlorophosphine
2) CAS NO.: 25979-07-1
3) Molecular Formula: C4H9Cl2P
4) Molecular Weight: 158.99
5) Structural:
6) Purity: Min98.0%
7) Appearance: White low-melting-point crystalline solid
8) Melting point : 39-41 °C(lit.)
9) Density: 1.2528 (rough estimate)10) Boiling point : 144 °C16 mm Hg(lit.)
11) Flash Point: 289 °F
12) Product Manager Email: Nicole@coreychem.com
3. Frequently Asked Questions (FAQ)
Question 1: Why is tert-butylphosphonous dichloride highly favored in the synthesis of chiral ligands?
The core advantage lies in its bulky “tert-butyl” structure. This steric hindrance provides excellent steric and electronic effects for the synthesized mono- and bidentate phosphine ligands (such as PCP pincer ligands), thereby delivering high selectivity and catalytic efficiency in asymmetric hydrogenation and other chiral catalytic reactions. It is a crucial building block for the R&D of advanced pharmaceutical molecules.
Question 2: What role do the two P-Cl bonds in the molecule play in practical synthesis?
These two P-Cl bonds are highly reactive and serve as excellent “reaction handles.” In practical operations, they readily undergo substitution, aminolysis, or alcoholysis reactions.
Question 3: Beyond pharmaceutical catalysis, what are its novel applications in advanced materials?
In the field of polymer materials, it can be used as a comonomer to copolymerize with olefin monomers, producing functional phosphorus-containing copolymers. These novel materials not only exhibit excellent flame-retardant and weather-resistant properties but also hold great application prospects in cutting-edge technologies such as organic light-emitting diodes (OLEDs) and solar cells.
Question 4: As a reagent extremely sensitive to air and moisture, how should it be handled safely in practice?
This product reacts violently with water, releasing toxic gases, and carries a risk of spontaneous combustion in air. Therefore, operations must be conducted in a glovebox or under strict inert gas protection, away from strong oxidizers and strong bases. Full protective gear, including gloves and safety goggles, is mandatory to prevent skin contact and inhalation. In case of accidental contact, rinse immediately with plenty of soapy water and seek medical attention promptly.
Question 5: What is the current spot availability, and can it meet the demands of bulk orders?
We offer premium spot inventory with a purity of over 98%, appearing as a white to pale yellow low-melting crystalline solid. As an independent manufacturer, we guarantee a stable supply for bulk orders. Additionally, we provide comprehensive technical support, including product spectra, Certificates of Analysis (COA), and professional testing methods, to ensure your R&D and production run smoothly.
4. Application Cases
Application 1 — Synthesis of PCP Pincer Ligands
It is a key precursor for synthesizing tert-butyl-functionalized 1,3-C6H4(CH2PR2)2 (PCP) pincer ligands. These ligands feature a stable structure and exhibit outstanding catalytic activity in asymmetric catalysis and transition metal coupling reactions.
Application 2 — Construction of the Dihydrobenzooxaphosphole Core
It can serve as a reactant in heterocyclic compound synthesis to build the dihydrobenzooxaphosphole skeleton, which is a vital core structure for various biologically active molecules and optoelectronic functional materials.
Application 3 — Synthesis of Imidazole Derivatives
By reacting with specific organic precursors, it can be used to prepare 2-(tert-butylphosphoryl)-1-phenyl-1H-imidazole derivatives. These phosphorus-containing heterocyclic compounds hold specific application value in pharmaceutical intermediates and coordination chemistry research.
Application 4 — Preparation of Chloro-phosphinite Reagents
It undergoes alcoholysis with alkoxides (such as sodium ethoxide) to efficiently produce chloro-phosphinite reagents, serving as crucial intermediates to further derive various phosphonite compounds.
Application 5 — Development of Organic Optical Information Recording Materials
In the field of optoelectronic materials, it is utilized to prepare phosphorus-containing copolymers with special optoelectronic properties. These materials have broad research and application potential in cutting-edge areas like color liquid crystal materials and organic optical information recording.
5. Safety and Storage
As a highly sensitive hazardous chemical reagent, it is intended for industrial and research use only.
This product reacts violently with water, releasing toxic gases, and carries a risk of spontaneous combustion in air.
It is highly susceptible to decomposition upon contact with water and must be stored in airtight containers under an inert gas atmosphere. Keep strictly away from moisture and oxidizing agents.
6. Product Manager Information
Product Manager: Nicole Zhao
Email: Nicole@coreychem.com
