Product description:
Spermidine trihydrochloride is a polyamine that inhibits neuronal nitric oxide synthase (nNOS) and binds and precipitates DNA. It may be used to purify DNA binding proteins.
Spermidine trihydrochloride (CAS: 334-50-9) is a salt form of spermidine, a naturally occurring polyamine that plays a crucial role in various cellular processes, including growth, differentiation, autophagy, and the regulation of gene expression.
Spermidine trihydrochloride appears as white to off-white crystalline powder, which is soluble in water(100mg/ml-clear, colorless solution), very hygroscopic, and air-sensitive.
Chemical Reactivity:
Spermidine trihydrochloride exhibits a range of chemical reactivity characteristics due to the presence of multiple amine groups. These chemical properties are central to spermidine’s biological effects, which include interactions with DNA, RNA, and various enzymes.
--Schiff Base Formation: Spermidine can form Schiff bases with aldehydes and ketones, important intermediates in organic synthesis, especially in protein chemistry and cellular interactions.
--Metal Ion Chelation: The nitrogen atoms of spermidine can coordinate with metal ions, such as zinc and iron, influencing the activity of metalloenzymes and supporting a variety of biochemical processes.
--Nucleophilic Reactions: As a polyamine, spermidine is nucleophilic and can react with electrophilic compounds, forming covalent bonds with reactive aldehydes, ketones, and other electrophiles. This reactivity is significant for its interaction with proteins and nucleic acids.
Benefits:
Spermidine trihydrochloride has been extensively studied for its potential health benefits, including its ability to modulate autophagy, enhance cardiovascular health, protect against neurodegenerative diseases, and exhibit antioxidant activity.
Studies have shown that it can enhance cardiovascular health by promoting blood vessel relaxation, reducing oxidative stress, and improving mitochondrial function. It has also been suggested to have neuroprotective effects and may contribute to cognitive health and brain function.
It has shown promising results in preclinical studies, demonstrating its ability to protect neurons, reduce inflammation, and enhance cellular resilience.
Application:
Spermidine Trihydrochloride is a NOS1 inhibitor and NMDA and T4 activator. Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. It was in a structural and functional study of polyamines, where potassium and sodium ions were found to promote different effects when binding with polyamines.
Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements.Spermidine inhibits NOS1 (nNOS). Spermidine activates PNK (polynucleotide kinase T4).
Spermidine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner.It has a diverse range of applications, particularly in cellular biology, pharmacology, and industrial chemistry.
Biological Activity :
Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [ 3 H]-MK801. Its biological activity as a polyamine, coupled with its ability to regulate key cellular functions, makes it a valuable tool in scientific research.
Spermidine trihydrochloride is an aliphatic polyamine. Its crystalline structure has been studied. It has been reported to preserve the nuclei and prevent proteolytic degradation of histones during the macronuclei isolation from Tetrahymena pyriformis.
Summary:
Spermidine trihydrochloride is a polyamine compound with significant biological activity and a wide range of chemical properties. Its role in regulating critical cellular functions such as autophagy, gene expression, and cell growth has made it an invaluable tool in scientific research, particularly in the fields of aging, neurodegenerative diseases, and cancer.
Its applications extend beyond biomedical research into industries such as cosmetics, polymer chemistry, and agriculture, demonstrating its versatility and wide-reaching potential.
The growing interest in spermidine trihydrochloride highlights the importance of polyamines in cellular regulation and underscores the potential for new treatments that harness the natural processes of cellular repair and regeneration.
Whether in the form of dietary supplements, therapeutic drugs, or industrial products, spermidine trihydrochloride’s applications are set to expand in the coming years, offering new opportunities for innovation across multiple industries.
Product manager: Joy Wu CONTACT/Email address: Joy@coreychem.com
