In the forefront fields of life sciences, drug development, and analytical chemistry, highly sensitive and selective detection technologies are the key to driving research breakthroughs. Fluorescence labeling has become an indispensable tool in these fields due to its excellent sensitivity and convenience.
Today, we are honored to introduce to you an important reagent in our core product line 4-bromomethyl-7-methoxycoumarin, a star molecule that has demonstrated outstanding performance in the field of fluorescence derivatization.
Product Core Information：
- English name: 4-Bromomethyl-7-methoxycoumarin
- Chinese name: 4-溴甲基-7-甲氧基香豆素
- Molecular formula: C ₁₁ H ₉ BrO3
- Molecular weight: 269.09
- CAS number: 35231-44-8
- Product Manager: ada@coreychem.com
What is 4-bromomethyl-7-methoxycoumarin?
4-bromomethyl-7-methoxycoumarin is a derivatization reagent based on coumarin structure. Coumarin itself is a classic fluorescent group with excellent optical properties. This product introduces two key functional groups in its molecular structure:
- 7-methoxy (- OCH 3) ：greatly enhances its fluorescence intensity, allowing it to emit strong blue fluorescence under ultraviolet light irradiation.
- 4-Bromomethyl (- CH ₂ Br): As an active alkylating group, it can efficiently react with nucleophilic groups such as carboxylic acids, thiols, etc.
This unique structural design makes it a perfect “bridge” that can covalently attach coumarin groups with strong fluorescent properties to the target molecule, thereby achieving fluorescent labeling and detection of the molecule.
Main application areas：
- HPLC/CE fluorescence derivatization reagent:
Carboxylic acid analysis: used to detect and quantify carboxylic acid substances such as fatty acids, bile acids, prostaglandins, etc. in biological samples (such as serum, urine), food, and plant extracts, with a detection limit of up to the level of femtolile (fmol).
Thiol compound analysis: used for efficient labeling and detection of biological thiols such as glutathione, cysteine, homocysteine, etc., is crucial in the study of oxidative stress and disease biomarkers.
- Biomolecular markers:
As a key intermediate for synthesizing more complex fluorescent probes, it can be used to label proteins, peptides, or other biomolecules for tracking their distribution and behavior in cell imaging or biosensing.
- Drug development and pharmacokinetic studies:
Used to label drug molecules or their metabolites for high-sensitivity tracking and quantitative analysis in complex biological matrices.
If you are interested in this molecule, you can contact us at any time: ada@coreychem.com
