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Sodium tetradeuterioborate-d4

September 16, 2026

CAS: 15681-89-7 ｜ Common deuterated reducing agents

1. Product Overview

Sodium tetradeuterioborate-d4, also known as Sodium borohydride, appears as a white or grayish-white solid at room temperature and normal pressure. It has a significant hygroscopic property and will deteriorate by dissolving and decomposing due to absorbing moisture when left in the air for a long time. Sodium borodeuteride is a derivative of borohydride sodium. Its physical and chemical properties are basically the same as those of borohydride sodium and can be used as an organic chemical synthesis reagent. It is mostly used to introduce deuterium atoms into molecular structure units. By utilizing the property that borodeuteride sodium and elemental iodine release borane, this substance is also frequently used in the synthesis of deuterated boranes, and has certain applications in basic chemical research.

2. Basic Product Information
1) Product Name: Sodium tetradeuterioborate-d4
2) CAS NO.: 15681-89-7
3) Molecular Formula: BD4Na
4) Molecular Weight: 41.86
5) Structural:

6) Purity: 99 atom%D,95%chemical purity
7) Appearance: Off-white crystalline powder
8) Sensitive: Moisture Sensitive
9) Density: 1.187 g/mL
10) Solubility: Soluble in liquid ammonia, amines and pyridine.
11) Melting point : >300 °C (dec.) (lit.)
12) Product Manager Email: Nicole@coreychem.com

3. Frequently Asked Questions (FAQ)

Question 1: What are the available purity grades of this product?

Two purity grades are offered:
Grade E090027: 98 atom % D, 95% chemical purity.
Grade E090041: 99 atom % D, 95% chemical purity.

Question 2: What are the key advantages of this product for long-term projects?

Key advantages include:
Self-developed synthesis process with controllable and stable deuterium abundance.
Scalable production from gram to kilogram levels to meet batch delivery needs.
Cost-effective alternative to imported products, suitable for long-term projects.

Question 3: What are the recommended storage conditions to maintain the stability and isotopic purity of Sodium Tetradeuterioborate-d₄?

Due to its sensitivity to moisture, NaBD₄ must be stored in a tightly sealed container under an inert atmosphere (such as nitrogen or argon). It should be kept in a cool, dry place, ideally refrigerated (2-8°C), to prevent hydrolysis and the exchange of deuterium with atmospheric moisture, which would compromise its isotopic purity.

Question 4: What are the primary safety hazards associated with handling Sodium Tetradeuterioborate-d₄, and how should it be handled?

Like its non-deuterated counterpart, NaBD₄ is a flammable solid and a strong reducing agent. It reacts violently with water, acids, and oxidizing agents to release flammable/deuterated hydrogen gas. It is also harmful if swallowed and causes severe skin burns and eye damage. It must be handled strictly inside a glove box or under an inert gas line, wearing appropriate PPE (gloves, goggles, lab coat).

Question 5: How should it be stored?

Storage: Keep in tightly closed containers, stored in a cool, dry place away from high temperature and contamination. Different viscosity grades should be stored separately with clear labeling to prevent mix-ups, and pharmaceutical-grade material must be strictly segregated from industrial-grade silicone oil.

4. Application Cases

Application 1 — Deuterium-Labeled Drug Synthesis

Used to introduce deuterium atoms into drug molecules during organic synthesis. Deuterium labeling helps study drug metabolism, pharmacokinetics, and mechanism of action, as deuterium’s stable isotope properties allow tracking of drug behavior in biological systems.

Application 2 — Isotope Tracing in Mechanism Research

Serves as a core reagent for isotope tracing experiments. By introducing deuterium at specific reaction sites, researchers can elucidate reaction mechanisms (e.g., reduction pathways, bond-breaking/forming processes) in organic or biochemical reactions.

Application 3 — Selective Reduction in Organic Synthesis

Acts as a mild reducing agent for selective reduction of functional groups (e.g., carbonyl groups, imines) in complex organic molecules. Its deuterated form allows simultaneous reduction and deuterium incorporation, enabling synthesis of deuterium-labeled intermediates for further reactions.

Application 4 — Deuterated Compound Synthesis for NMR Spectroscopy

Provides deuterium atoms to synthesize deuterated solvents or internal standards for nuclear magnetic resonance (NMR) spectroscopy. Deuterated compounds reduce background signals in NMR, improving spectral resolution for structural analysis of organic molecules.

Application 5 — Deuterium-Labeling in Biochemical Studies

Used to label biomolecules (e.g., amino acids, sugars) with deuterium. This facilitates studies on biomolecular structure, dynamics, and interactions (e.g., protein-ligand binding, enzyme catalysis) using techniques like mass spectrometry or NMR, leveraging deuterium’s distinct isotopic signature.

5. Safety and Storage

It is stable under normal temperature and pressure, it can be hydrolyzed in moist air.

It must be stored in the inert gas in a cool, dry ventilated place.

6. Product Manager Information
Product Manager: Nicole Zhao
Email: Nicole@coreychem.com