Overview: Ademetionine Disulfate Tosylate (CAS: 97540-22-2), also known as S-Adenosyl-L-methionine disulfate tosylate or SAMe disulfate tosylate, is a stabilized salt form of SAMe, a naturally occurring bioactive substance essential for biological processes in human body. This compound serves as a crucial research tool in biochemical and pharmaceutical investigations.It is manufactured through synthetic procedures involving the reaction between adenosine triphosphate (ATP) and methionine. Ademethionine Disulfate Tosylate is typically used for its therapeutic effects, which range from improving liver function to providing relief from depression and arthritis. Biochemical Role: Ademetionine Disulfate Tosylate functions as the principal biological methyl donor synthesized in all mammalian cells, with the highest abundance found in the liver. It serves as a precursor for transmethylation, transsulfuration, and aminopropylation reactions in cellular metabolism. It participates in regulating gene expression and the synthesis of brain neurotransmitters, including dopamine and serotonin, thereby supporting mood health and emotional well-being. Additionally, it is involved in glutathione synthesis, contributing to the body's antioxidant defense system and liver detoxification capacity. And SAMe-ST significantly increased Na+.K(+)-ATPase activity.
Pharmacological Applications: --Hepatoprotective Effects Ademetionine has been extensively studied for its hepatoprotective properties. Research has demonstrated its ability to promote hepatic glutathione synthesis in chronic liver disease. In animal models, S-adenosylmethionine administration abolished mortality in acetaminophen-induced hepatotoxicity when given within one hour following acetaminophen exposure (0 of 32 vs. 13 of 49, p < 0.005). The mixed disulfate/tosylate salt form significantly reduced mortality in C3H mice treated with acetaminophen (0 of 24 vs. 4 of 18; p < 0.05). The compound exhibits anti-inflammatory activity and has been used in studies of chronic liver disease. Clinical applications include liver function maintenance in conditions such as fatty liver and cirrhosis, improvement of membrane fluidity, enhancement of Na⁺-K⁺-ATPase activity, and repair of the cellular cytoskeleton. --Mood and Joint Health Support SAMe disulfate tosylate is widely used for mood health support, liver function maintenance, and joint comfort. It participates in synthesis of brain neurotransmitters that support emotional well-being and has been shown to help alleviate symptoms associated with osteoarthritis. --Intrahepatic Cholestasis Treatment Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. A decrease in SAMe levels can cause bile stasis. In chronic liver disease patients who often develop intrahepatic cholestasis (IHC) — which can further exacerbate liver damage and potentially lead to cirrhosis, liver failure, or death — extracorporeal supplementation of SAMe is an important treatment approach for improving IHC. Conclusion: SAMe-ST is a multifunctional biochemical agent exhibiting antidepressant, anticancer and hepatoprotective properties. Its comprehensive biochemical functions, ranging from methylation reactions and antioxidant defense to neurotransmitter synthesis, make it a valuable compound for pharmaceutical and biochemical research. Its applications span liver disease studies, mood health investigations, and enzyme mechanism research, establishing it as a significant tool in the advancement of biomedical sciences. Product manager: Joy Wu Contact/Email address: Joy@coreychem.com
