Product Manager: Selina Zhang; Email: selina@coreychem.com
| Product Name | 1H-Imidazole-1-sulfonyl azide hydrochloride |
| Synonyms | 1H-Imidazole-1-sulfonylazidehydrochloride;Imidazole-1-sulfonylazidehydrochloride;1H-Imidazole-1-sulphonylazidehydrochloride;Imidazole-1-sulfonylazideHCl;1H-ImidaChemicalbookzole-1-sulfonylAzideHydrochlorideSalt;Imidazole-1-sulfonylazide,HClsalt;N-diazoimidazole-1-sulfonamidehydrochloride;1H-Imidazole-1H-sulfonylazide,HClsalt,95%min |
| CAS NO | 952234-36-5 |
| Purity |
97% |
| Appearance |
White to off-white solid |
| MF | C3H3N5O2S.HCl |
| MW | 210 |
| Contact | selina@coreychem.com |
1H-Imidazole-1-sulfonyl azide hydrochloride (CAS: 952234-36-5) is a highly versatile azide reagent widely used in organic synthesis, pharmaceutical research, and functional compound development. Featuring a stable imidazole-sulfonyl azide core, it offers excellent reactivity for diazo transfer, azide introduction, and heterocycle functionalization. Its primary applications are outlined below:
1. Organic Synthesis & Pharmaceutical Research
Diazo Transfer & Azide Functionalization
The sulfonyl azide group enables efficient introduction of azide moieties and diazo transfer reactions, facilitating the synthesis of nitrogen-rich heterocycles, bioactive scaffolds, and potential drug candidates.
Intermediate for Bioactive Molecules
1H-Imidazole-1-sulfonyl azide hydrochloride serves as a key reagent for constructing functionalized heterocycles and nitrogen-containing intermediates, supporting structure–activity relationship (SAR) studies, medicinal chemistry optimization, and library synthesis.
2. Advanced Material & Functional Compound Development
Functional Nitrogen-Rich Compounds
Its high reactivity allows incorporation into azide-functionalized polymers, ligands, and small molecules, enabling the development of advanced materials, bioorthogonal probes, and chemical biology tools.
Specialty Chemical Applications
It is widely employed as a building block for the synthesis of triazoles, click chemistry derivatives, and heterocyclic intermediates in both research and industrial contexts.
3. Research & Development Applications
Reaction Exploration & Method Development
Researchers use this compound to investigate azide-based transformations, optimize reaction conditions, and explore structure–reactivity relationships in nitrogen-rich systems.
Process Optimization & Laboratory Synthesis
Its stable and well-defined structure makes it suitable for method development, small-scale synthesis, and reproducible laboratory experimentation.
4. Handling & Storage
Storage Conditions
Store in tightly sealed containers under cool, dry, and light-protected conditions. Avoid heat and moisture to maintain stability and prevent decomposition.
Intended Use
1H-Imidazole-1-sulfonyl azide hydrochloride is intended for research, development, and industrial synthesis applications. It is not for direct pharmaceutical or food use without proper regulatory approval.
Summary
The value of 1H-Imidazole-1-sulfonyl azide hydrochloride lies in its combination of a reactive sulfonyl azide group and a stable imidazole core. This structure enables efficient synthesis of nitrogen-rich intermediates, heterocycles, and functional compounds, supporting innovation in medicinal chemistry, advanced materials, and specialty chemical development.
