Product Name:Quinine hydrochloride
CAS: 6119-47-7
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Appearance |
White or almost white or colourless, fine, silky needles, often in clusters |
Conform |
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Solubility |
Soluble in water and freely soluble in ethanol 96%. |
Conform |
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Test Chromatogram TLC |
The principal spot sample similar with the reference solution |
Conform |
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Test Bromine and Ammonia |
A green colour develops |
Conform |
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Test Fluorescence |
An intense blue fluorescence appears which disappear on addition of hydrochloric acid |
Conform |
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Test Characteristic of chlorides |
The solution gives the reaction of chlorides |
Conform |
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Test for pH |
6.0 to 6.8 |
6.50 |
Pharmacological Mechanisms and Properties
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Antimalarial Mechanism: As a weak base, quinine can concentrate within the acidic food vacuoles of the malaria parasite, interfering with its hemoglobin digestion process. This leads to the accumulation of toxic heme, thereby killing the parasite. It is also lethal to the gametocytes of Plasmodium vivax and Plasmodium malariae.
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Ion Channel Effects: Quinine is a known potassium channel blocker. Furthermore, it can reversibly inhibit gap junction channels formed by proteins such as connexin Cx36, which is significant for neuroelectric signal transmission research.
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Physicochemical and Safety Properties:
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Solubility: Freely soluble in water (approximately 62.5 g/L at 20°C) and ethanol; slightly soluble in ether.
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