Vinylbenzyl chloride

CAS NO.：30030-25-2

Purity: ≥99%
Appearance: Colorless Transparent Liquid

Product Manager Email:ada@coreychem.com

Product name	Vinylbenzyl chloride
Synonym	(chloromethyl)ethenyl-benzen;(chloromethyl)ethenyl-Benzene;Vinylbenzyl chloride, 95%, mixture, stabilized with TBC
CAS NO.	30030-25-2
Appearance	Light yellow to colorless liquid
Purity	≥97%
MF	C9H9Cl
MW	152.62
Related categories	Halogenated compounds; Zhishang Chemical Intermediate
Transport Information	Not dangerous goods
HS Code	2903999090
Structural formula
Product Manager Email:	ada@coreychem.com

Frequently Asked Questions

1. What are the main uses of chloromethyl vinyl benzene?

It is an important organic synthesis intermediate and functional monomer. Due to the presence of both reactive chloromethyl (- CH ₂ Cl) and polymerizable vinyl (- CH=CH ₂) groups in the molecule. This product can be applied to the following two fields:
1）In the field of polymer materials:
As a monomer, it can copolymerize with monomers such as styrene to adjust the flexibility, hardness, heat resistance, and other properties of polymers, and is applied in fields such as plastics, coatings, and adhesives.
2）Organic synthesis intermediates:
The high reactivity of chloromethyl allows it to react with various nucleophiles and be used to construct more complex drug molecules or organic functional materials.

2.How dangerous is it?

It is dangerous. It is a corrosive, toxic, and environmentally harmful substance.
1）Health hazards: Swallowing, inhalation, or skin contact are all harmful. Irritating to the skin and eyes, and may cause skin allergic reactions.
2）Environmental hazard: Highly toxic to aquatic organisms and has long-term and sustained effects. Its 96 hour median lethal concentration (LC50) for fish is as low as 0.31 mg/L.
3）Physical hazard: Flammable, its vapor is heavier than air and may spread along the ground. Under strong heating, it may form explosive mixtures with air.

3.Is it classified as dangerous goods during transportation?

Belonging to dangerous goods.
According to the safety data sheets of some suppliers, their UN number is UN2922, hazard categories are 8 (corrosive) and 6.1 (toxic), and packaging category is II (highly hazardous). During transportation, it is necessary to strictly comply with the regulations for transporting dangerous goods.

4.How to store safely?

1）Temperature and environment: It should be stored for a long time at a low temperature of 2-8 ° C, in a cool, dry, well ventilated place, and the container should be kept sealed.
2）Inert atmosphere: It is recommended to store under inert gas (such as nitrogen) protection to prevent oxidation or polymerization.
3）Adding stabilizers: Products typically contain stabilizers (such as 500 ppm tert butylcatechol (TBC)) to prevent spontaneous polymerization. Be careful not to damage the stabilizer system during storage and sampling.

5.What protective measures should be taken when using it?

1）Respiratory protection: Prevent inhalation of vapors or aerosols. If vapors may be generated, appropriate respiratory protective equipment should be worn.
2）Eye and face protection: Close fitting safety goggles must be worn.
3）Body protection: Wear appropriate protective clothing and gloves to avoid skin contact.

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Application 1: Ion exchange resin and adsorbent materials

This is one of the most classic and important applications of chloromethyl vinyl benzene.
Macroporous or gel type polymer microspheres can be obtained by copolymerizing them with crosslinking agents such as divinylbenzene (DVB) as monomers. The chloromethyl group on the polymer skeleton is a key active site, suitable for preparing anion exchange resins; Preparation of chelating resin and preparation of ultra-high crosslinking adsorption resin.

Application 2: Photoresist and Electronic Chemicals

Due to its high purity and reactivity, chloromethylvinylbenzene is an important raw material in the fields of semiconductors and microelectronics.
1）Photoresist resin: used for synthesizing high-performance negative photoresist, including E-beam photoresist, which is a key material for manufacturing fine circuit patterns.
2）Advanced packaging materials: used as core polymer monomers for manufacturing dielectric materials required in advanced chip packaging.

Application 3: Drug Delivery System

Poly (VBC), a polymer based on chloromethyl vinyl benzene, is an ideal platform for constructing advanced drug delivery systems (DDS).
1）Controllable functionalization: The chloromethyl group on its polymer backbone can easily connect to targeted ligands (such as antibodies, peptides), therapeutic drugs, or hydrophilic polymers (such as polyethylene glycol PEG) through chemical reactions.
2）Precise regulation: Through controllable free radical polymerization techniques such as RAFT and ATRP, polymers with narrow molecular weight distribution and clear structure can be prepared, thereby precisely regulating drug release kinetics and biocompatibility.
3）Cross linked carrier: using its bifunctional group characteristics, it can be used as a cross-linking agent to build hydrogels or nanoparticles that can wrap drugs. The diffusion and release rate of drugs can be controlled by adjusting the cross-linking density.

Application 4: Solid phase synthesis carrier for peptides

Chloromethylated polystyrene resin is a classic Merrifield resin and a key tool for solid-phase peptide synthesis. Chloromethyl, as a connecting arm, can covalently fix the carboxyl group of the first amino acid on the resin, thereby achieving automated and efficient synthesis of polypeptide chains.

Application 5: Catalyst Carrier and Organic Synthesis Intermediates

1）Catalyst carrier: PVBC can be used as an excellent solid carrier to chelate metal ions (such as palladium) through chloromethyl anchored ligands, forming heterogeneous catalysts. This catalyst is easy to separate and recover from the reaction system, reusable, and exhibits high catalytic activity in coupling reactions such as Suzuki Miyaura and Heck.
2）Organic synthesis intermediates: In addition to being used for polymerization, chloromethylvinylbenzene itself is also an important fine chemical intermediate. It can participate in basic research as an “allylation reagent”, react with organosilicon reagents, or synthesize various compounds such as new photosensitive materials and flame retardants through its reactive groups.