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White to beige powder MF: C19H32O4 MW: 324.45
Synonyms: TOFA;5-(tetradecyloxy)-2-furancarboxylicaci;5-tetradecyloxy-2-furonicacid;mdl14514;RMI-14514;TOFA (5-(Tetradecyloxy)-2-furoic acid);5-(TETRADECYLOXY)-2-FURANCARBOXYLIC ACID;5-(TETRADECYLOXY)-2-FUROIC ACID
| Melting point | 112-115 °C |
| Boiling point | 441.7±25.0 °C(Predicted) |
| density | 1.003±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 2.5 mg/mL |
| form | solid |
| Purity | 98% |
| color | white to beige |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1).1 Induces apoptosis in a variety of tumor cell lines.2,3 Stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells. TOFA impairs glucose-stimulated insulin secretion after chronic treatment.
TOFA has been used as a lipid biosynthesis inhibitor in mesenchymal stromal cells (MSCs), human pluripotent stem cells., an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines., a lipolysis inhibitor in cancer stem cells (CSCs).5-(Tetradecyloxy)-2-furoic acid (TOFA) elicits hypolipidemic?functionality by favoring fatty acid breakdown and at the same time preventing biosynthesis. It induces apoptosis in pancreatic cancer cells and favors tumor suppression.
CONTACT/Email address: Joy@coreychem.com
1kg,5kg in Bag or Bottle;10kg,20kg,25kg in Fiber Can; Packing according to requirements.
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