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MF: C47H82N4O15 MW: 943.17
It is an intermediate of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes.
Synonyms: Semaglutide Side Chain; Semaglutide Active Ester Modifier; Semaglutide Side Chain NHS Activated Ester;Fmoc-L-Lys[OctotBu)-Glu-(otBu)-AEEA-AEEA]-OSu; tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu;
| Density | 1.15±0.1 g/cm3(Predicted) |
| pka | 14.18±0.46(Predicted) |
| CAS No. | 1118767-15-9 |
| Purity | 95% |
| Appearance | Yellowish liquid |
| Storage | Store at -20±5°C |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
The Semaglutide Side Chain (tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu) is a crucial protecting group for side chains in peptide synthesis. It exhibits excellent solubility and stability, effectively safeguarding amino acid side chains from nonspecific modifications or degradation during chemical reactions. Widely used in solid-phase peptide synthesis and subsequent functional group modifications, the Semaglutide Side Chain helps control reaction conditions and selectivity, minimizing side reactions to enhance product purity and yield.
Drug Modification: tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is utilized in modifying small molecule drugs, proteins, antibodies, and other bioactive molecules. By forming stable amide bonds, it enhances drug solubility, stability, or targeting specificity, thereby improving therapeutic efficacy and safety. Particularly significant in the development of long-acting peptide drugs like Semaglutide, it plays a critical role in optimizing pharmacokinetic properties and therapeutic effects.
Targeted Drug Delivery: Leveraging its high reactivity and biocompatibility, tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is employed in constructing targeted drug delivery systems. This facilitates precise drug release within specific tissues or cells, enhancing therapeutic efficacy while reducing side effects.
CONTACT/Email address: Joy@coreychem.com
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