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White powder MF:C39H66N4O15 MW:830.96 Ste-Glu-AEEA-AEEA-OSU is an intermediate of semaglutide, a glucagon-like peptide-1 (GLP-1) analog with significant hypoglycemic efficacy. Synonyms: Octa(OtBu)-Glu(ɑ-OtBu)-AEEA-AEEA)-OR;Ste-Glu-AEEA-AEEA-OSU;18-[[(1S)-1-carboxy-4-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxo-ethoxy]ethoxy]ethylamino]-2-oxo-ethoxy]ethoxy]ethylamino]-4-oxo-butyl]amino]-18-oxo-octadecanoic acid;
| density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Storage temp. 2-8°C |
| form | white to off-white powder |
| pka | 3.52±0.10(Predicted) |
| Appearance | White to off-white Solid |
| Purity | 98% |
| safety info | Non DG |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
Deprotection effect: During the drug synthesis process, certain functional groups need to be protected to prevent unnecessary modification or degradation during the reaction. The somalupetide deprotection active ester modifier can remove these protective groups under appropriate conditions, exposing the target functional groups and enabling the next chemical reaction.
Active ester modification: The succinimidyl ester (OSu) group in this modifier is an active ester that can efficiently react with amino groups and other functional groups to form stable amide bonds. This property enables the somalupetide deprotection active ester modifier to be used for modifying small molecule drugs, proteins, antibodies and other bioactive molecules, enhancing the water solubility, stability or targeting properties of the drugs by forming stable amide bonds.
Improving drug performance: Through the modification with the somalupetide deprotection active ester modifier, the pharmacokinetic properties and therapeutic effects of the drug can be significantly improved. For example, in the development of long-acting peptide drugs such as somalupetide, this modifier can be used as a side chain modifier, significantly increasing the biological half-life and bioavailability of the drug.
CONTACT/Email address: Joy@coreychem.com
Package Size: 1g/bottle、10g/bottle、100g/bottle; KGs inbottle
Storage: Store at -20±5℃, keep dry.
Packing according to customer’s requirements.
