(S)-(-)-1,2-Diaminopropane dihydrochloride

Product name	(S)-(-)-1,2-Diaminopropane dihydrochloride
Synonym	L-1,2-PROPANEDIAMINE DIHYDROCHLORIDE;PROPYLENEDIAMINE DIHYDROCHLORIDE;(S)-(-)-1,2-DIAMINOPROPANE DIHYDROCHLORIDE;(S)-1,2-DIAMINOPROPANE DIHYDROCHLORIDE;(S)-1,2-PROPANEDIAMINE DIHYDROCHLORIDE
	19777-66-3
Appearance	White or off-white powder
Purity	≥99%
MF	C3H11ClN2
MW	110.59
Related categories	Chiral building block；intermediate
Transport Information	Not dangerous goods
Product photo
Product Manager Email:	jessie@coreychem.com

Frequently Asked Questions

Question 1:What are the basic physical properties of (S)-(-)-1,2-Diaminopropane dihydrochloride（CAS NO.: 19777-66-3）?

(S)-(-)-1,2-Diaminopropane dihydrochloride is a white to off-white crystalline powder. Its molecular formula is C₃H₁₀N₂·2HCl, and its molecular weight is 147.04. It is soluble in water and typically has a specific optical rotation of [α]²⁰/D ≈ -4° (c=20, H₂O). The melting point is approximately 227-229°C (with decomposition). It is hygroscopic and should be stored under inert gas in a cool, dark place.

Question 2:In terms of its application, what are the key features of this product?

(S)-(-)-1,2-Diaminopropane dihydrochloride is a chiral C3-diamine building block widely used in asymmetric synthesis and pharmaceutical development. Its most significant feature is its role as the designated starting material for the synthesis of dexrazoxane, an FDA-approved cardioprotective drug used to prevent anthracycline-induced cardiotoxicity. The (S)-enantiomer is essential; the (R)-enantiomer is an unsuitable byproduct of the resolution process. It is also used in the preparation of chiral imidazoline derivatives and chiral NMR shift reagents such as (S)-PDTA.

Question 3:What role does this product play in pharmaceutical and therapeutic applications?

This compound serves as a critical chiral synthon in the pharmaceutical industry. It is the non-negotiable precursor for dexrazoxane, where strict enantiomeric purity (typically requiring ≤0.1% of the (R)-enantiomer) is mandatory for regulatory compliance and drug efficacy. The (S)-configuration provides the correct three-dimensional geometry necessary for biological activity. Additionally, it is employed in synthesizing chiral ligands and other optically active pharmaceutical intermediates where stereochemical integrity directly impacts therapeutic outcomes.

Question 4:How should this product be stored and handled?

It should be stored in a tightly closed container under inert gas, in a cool, dark, and well-ventilated area at room temperature. The compound is hygroscopic and sensitive to moisture, so exposure to humid air should be minimized. Handling should be performed with appropriate personal protective equipment (gloves, eye protection, dust mask) in a well-ventilated environment. It is generally classified as a non-dangerous good for transport but should be kept away from strong oxidizing agents and incompatible substances.

Question 5:How does the stability or formulation of this product affect its actual performance?

The dihydrochloride salt form offers improved stability and handling convenience compared to the free base, ensuring reliable chiral integrity during multi-step synthesis. However, the compound is hygroscopic, meaning it can absorb moisture from the air, which may affect weighing accuracy and long-term storage stability if not properly protected. For pharmaceutical applications, maintaining the enantiomeric purity is paramount; any racemization or contamination with the (R)-enantiomer during storage or handling would render the material unsuitable for dexrazoxane synthesis. Proper storage under inert gas at controlled temperature is critical to preserving both chemical and stereochemical integrity .