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White to off-white powder; Purity 99% ( NON-GMO;NON-Allergen;NON Animal origin) MF: C9H12N2O6 MW: 244.2
Synonyms: PSEUDOURIDINE;5-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione;5-β-D-ribofuranosyluracil;BETA-PSEUDOURIDINE;B-Pseudouridine;5-β-D-Ribofuranosyl-1,2,3,4-tetrahydropyrimidine-2,4-dione;5-β-D-Ribofuranosylpyrimidine-2,4(1H,3H)-dione;
Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;Heterocycles;Nucleotides;Pharmaceutical;Nucleosides
Pseudouridine, the most abundant modified nucleoside in non-coding RNAs, enhances the function of transfer RNA and ribosomal RNA by stabilizing RNA structure.
| Melting point | 222 °C |
| density | 1.641±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Very Slightly, Heated), Water (Slightly, Sonicated, Heated) |
| pka | 8.52±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| Purity | 99% |
| biological source | synthetic (chemical) |
| Water Solubility | water: soluble |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine. It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. Pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.
It is An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
Pseudouridine is essential for rRNA folding and for regulating translational accuracy and it is required for stabilizing the tRNA structure. Pseudouridine in rRNA and tRNA has been shown to fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation.
CONTACT/Email address: Joy@coreychem.com
100G,1kg,5kg in aluminium foil Bag or Bottle;10kg,20kg,25kg in Fiber Can; Packing according to requirements.
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