PODOPHYLLUM RESIN

✨Basic Properties
Product Name: Podophyllum Resin / Podophyllum Root Resin / Podophyllum Resin

CAS Number: 9000-55-9

Source: Dried rhizomes of plants from the Berberidaceae family (e.g., Podophyllum peltatum, Podophyllum tetrapodum)

Main Components: Complex mixture containing various lignan compounds such as podophyllotoxin and 4-demethylpodophyllotoxin

Appearance: Commercially available solutions are typically brownish-yellow liquids with a distinctive odor; extracts may be light yellowish-brown to brownish-yellow powders

🔬Core Characteristics
Strong Cytotoxicity: Exhibits cytotoxic and antimitotic effects, inhibiting viral DNA replication and tubulin polymerization to kill viruses and proliferating cells.

Potent Action: As a topical agent, it strongly corrodes and destroys wart tissue; improper use may cause damage to healthy tissue.

Systemic Absorption Risk: Despite topical application, extensive use or application to broken skin may allow absorption into the bloodstream, potentially triggering severe systemic toxic reactions (e.g., sensory abnormalities, intestinal obstruction, bone marrow suppression).

Significant Toxicity: The oral median lethal dose (LD50) is 45.83 mg/kg (mice), classifying it as a toxic substance. Ingestion or overdose may cause gastrointestinal reactions, liver and kidney damage, and neurological toxicity.

📚Primary Applications
Podophyllin applications primarily focus on two major areas: clinical treatment and pharmaceutical raw materials:

Dermatological Treatment: Primarily used for treating various viral warts such as genital warts, common warts, flat warts, and plantar warts. Typically, a 25% solution is applied directly to the affected area by medical personnel.
Anti-tumor Raw Material: Serves as a crucial pharmaceutical intermediate for semi-synthetic anti-tumor drugs like etoposide (VP-16) and teniposide (VM-26). These derivatives undergo structural modifications to reduce the toxicity of the original compounds, making them suitable for cancer chemotherapy.
Research Applications: Used in laboratory studies to investigate its antiviral, antibacterial, and anti-tumor mechanisms.

⚠️ Precautions for Use
Due to the product’s high toxicity and potent effects, several critical points require special attention:

Strictly Prohibit Self-Administration: Podophyllin is a prescription drug that must be administered by a physician. Direct dispensing to patients for self-use is strictly prohibited.

Absolute Contraindications: Pregnant women, diabetics, steroid users, individuals with poor blood circulation, and those with inflammation or bleeding around the wart site are absolutely prohibited from using this product.

Protect surrounding skin: Apply precisely to the wart itself, avoiding contact with healthy skin or eyes.

Control dosage and area: Do not treat large areas or multiple warts in a single application. A single dose should not exceed 1.0 ml to prevent systemic absorption and toxicity.

📞Contact information:

Contact: Lucy Yao

Email: lucy@coreychem.com