Plant extract Icaritin CAS-No-118525-40-9

CAS NO.：118525-40-9

MF: C21H20O6 MW: 368.38
Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from epimedium.
Icaritin is a hydrolytic product of Icariin, a traditional Chinese herbal medicine extracted from the Epimedium genus.
Icaritin and Desmethylicaritin, is two metabolites of Icariin, dramatically inhibit the growth of most malignant cells.
Purity above 98%; Heavey metal≤10ppm;
Residue on Ignition≤2.0%; Total Plate Count≤1000cfu/g

Purity	98% above
Heavy metal	≤10ppm
Residue on Ignition	≤2.0%

Melting point	239℃
Boiling point	582.0±50.0 °C(Predicted)
density	1.359
Fp	206.7℃
storage temp.	2-8°C
solubility	DMSO: soluble5mg/mL, clear (warmed)
form	powder
pka	6.44±0.40(Predicted)
color	light yellow to dark yellow
Total Plate Count	≤1000cfu/g
Product manager	Joy Wu; Email: Joy@coreychem.com

Icaritin is a hydrolytic product of Icariin, a traditional Chinese herbal medicine extracted from the Epimedium genus.
Icaritin and Desmethylicaritin, is two metabolites of Icariin, dramatically inhibit the growth of most malignant cells. They also have significant antiangiogenesis properties, inhibiting or eliminating entirely the development of new malignant cells.
Icaritin has been used in trials studying the treatment of Solid Tumors, Metastatic Breast Cancer, and Hepatocellular Carcinoma (HCC).

CONTACT / Email address: Joy@coreychem.com

Icaritin is a component of Epimedium flavonoid isolated from Herba Epimedii, which enhances osteoblastic differentiation of mesenchymal stem cells (MSCs) while it inhibits adipogenic differentiation of MSCs by inhibiting PPAR-g pathway. Icaritin has no effect on MSCs proliferation. Also, icaritin potently inhibits chronic myeloid leukemia (CML) and breast cancer cells proliferation most likely by modulation of MAPK/ERK/JNK and JAK2/STAT3 /AKT signaling. As other flavonoids, icaritin may exert estrogen-like activities.

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