N,N’-Diisopropylcarbodiimide

CAS NO.：693-13-0

Purity: ≥99%

Appearance: Colorless to light yellow liquid

Product Manager Email：jessie@coreychem.com

Product name	N,N’-Diisopropylcarbodiimide
Synonym	Carbodiimide,diisopropyl-;diisopropyl-carbodiimid;Diisopropylcarbodiimide;N,N’-Diisopropylcarbodiimide≥99%(AssChemicalbookay);N,N’-Diisopropylcarbodiimideforsynthesis;n,n’-methanetetraylbis(2-propanamine);N,N-DIISOPROPYLCARBODIIMIDE
	693-13-0
Appearance	Colorless to light yellow liquid
Purity	≥99%
MF	C7H14N2
MW	126.2
Related categories	Condensing agent; organic chemical raw material
Transport Information	Class 6.1 dangerous goods
Product photo
Product Manager Email:	jessie@coreychem.com

Frequently Asked Questions

Question 1:What are the basic physical properties of N,N’-Diisopropylcarbodiimide（CAS NO.: 693-13-0）?

N,N’-Diisopropylcarbodiimide is a colorless to light yellow transparent liquid with the molecular formula C₇H₁₄N₂ and a molecular weight of 126.20. Its density is approximately 0.815 g/mL (20°C), and its boiling point is 145-148°C. It is miscible with most organic solvents such as ether, tetrahydrofuran, and dichloromethane, but insoluble in water.

Question 2:In terms of its application, what are the key features of this product?

The core feature of DIC is its role as a highly efficient dehydrating condensing agent, used to activate carboxyl groups and promote the rapid condensation of carboxylic acids with amines to form amides. Compared with the commonly used DCC (dicyclohexylcarbodiimide), DIC is a liquid at room temperature, making it easier to handle; moreover, its byproduct diisopropylurea (DIU) has better solubility in organic solvents, simplifying product workup.

Question 3:What role does this product play in pharmaceutical and organic synthesis?

DIC is an important condensing agent used as a replacement for DCC in peptide synthesis. It is widely used in the synthesis of amides, anhydrides, aldehydes, ketones, isocyanates, and other compounds, and is a key reagent in drug synthesis (such as a dehydrating agent for amikacin and glutathione) and fine chemical fields.

Question 4:How should this product be stored and handled?

It should be stored in a dry, cool, and well-ventilated place, with the container kept tightly closed and away from heat and ignition sources. DIC is sensitive to moisture and decomposes upon contact with water, so storage under inert gas is recommended. Handling should be performed in a fume hood, wearing goggles, solvent-resistant gloves, and protective clothing, avoiding inhalation of vapors or contact with skin and eyes.

Question 5:What are the main impurities or quality control specifications of this product?

DIC is generally evaluated against several key quality parameters, including purity, water content, residual dichloromethane (DCM), and appearance (colorless to light yellow transparent liquid). Of these, water content plays the most critical role in condensation efficiency — if it exceeds the limit, DIC can hydrolyze and become ineffective. Residual dichloromethane is another important specification, particularly for pharmaceutical-grade material, which must comply with stringent residual solvent limits to meet regulatory standards.

Application 1:What is the role of N,N’-Diisopropylcarbodiimide（CAS NO.: 693-13-0） in the Pharmaceutical Field?

In the pharmaceutical field, DIC is a key dehydrating condensing agent widely used in the synthesis of peptide drugs and active pharmaceutical ingredients. It activates carboxyl groups to promote the efficient formation of amide bonds between carboxylic acids and amines, making it a core reagent for constructing peptide chains and drug molecules. For example, in the synthesis of drugs such as amikacin and glutathione, DIC serves as a dehydrating agent in key steps. Compared with DCC, DIC’s byproduct diisopropylurea (DIU) is easier to remove, which helps improve drug purity and makes it favored in the pharmaceutical industry.

Application 2:What is the role of this product in Peptide Synthesis?

In peptide synthesis, DIC is often used in combination with additives such as HOBt or Oxyma for carboxyl activation and amide bond formation. It effectively suppresses racemization during the reaction, improving peptide yield and optical purity. Since DIC is a liquid at room temperature, it is easy to measure accurately and handle in automated operations, making it particularly suitable for solid-phase peptide synthesis (SPPS) and large-scale liquid-phase peptide synthesis. It is an important alternative to DCC in peptide drug production.

Application 3:What is the use of this product in Organic Synthesis?

In organic synthesis, DIC is used not only for amide formation but also for preparing anhydrides, aldehydes, ketones, isocyanates, and other compounds. It can act as a carboxylic acid activator in esterification reactions and can also be used to synthesize reactive intermediates such as acylurea compounds. In addition, DIC is applied in heterocyclic compound synthesis and total synthesis of natural products, making it a commonly used condensing reagent in the fine chemical industry.

Application 4:What is the role of this product in the Pesticide and Fine Chemical Fields?

In the pesticide and fine chemical fields, DIC can be used to synthesize pesticide intermediates containing amide bonds. Many modern pesticide molecules (such as certain herbicides and insecticides) contain amide structures, and DIC can efficiently catalyze amide bond formation to help construct the target molecular skeleton. In addition, it is also used in the synthesis of intermediates for dyes, pigments, and various fine chemicals, demonstrating practical value in pesticide and fine chemical production.

Application 5:What are the potential applications of this product in the Field of Materials Science?

In materials science, DIC can be used for the modification and functionalization of polymer materials. For example, it can activate carboxyl groups to graft functional molecules onto polymer chains, thereby imparting new properties such as hydrophilicity, biocompatibility, or specific recognition capability. In addition, DIC can also be used to synthesize polyamides, polyimides, and other polymer materials, showing potential applications in functional coatings, biomedical materials, and separation membranes.