Nicotinamide riboside chloride;NR-Cl CAS 23111-00-4

Nicotinamide Riboside Chloride is a crystal form of Nicotinamide riboside (NR) chloride termed NIAGEN, generally recognized as safe (GRAS) for use in foods and in dietary supplements. 
Nicotinamide Riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. 
Nicotinamide riboside is a newly discovered NAD (NAD+) precursor vitamin.

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Nicotinamide riboside (NR) is a naturally occurring vitamin B-3 present in the human diet that acts as an NAD+ precursor and is suggested to improve mitochondrial function and insulin sensitivity. 
NR acts via activation of the NAD+-dependent sirtuin enzyme family, thereby regulating oxidative metabolism. 
In vitro experiments of NR supplementation have shown its successful NAD+-restoring capability and subsequent increased oxidative gene expression in skeletal muscle cells. 
Results from in vivo mouse models have shown improvements in insulin sensitivity and oxidative energy metabolism, including enhanced metabolic flexibility, increased aerobic exercise capacity, 
and indications of improved mitochondrial biogenesis.