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White to off-white powder MF: C10H14N2O6 MW: 258.229
Product Categories: Pharmaceutical;Nucleotides;Nucleosides;Nucleosides-Pseudouridine Nucleosides
N1-Methylpseudouridine is a modified nucleoside used for enhancing mRNA translation. Incorporation of N1-Methylpseudouridine into mRNA turns off the immune/eIF2α phosphorylation-dependent inhibition of translation, and increases ribosome pausing and density on the mRNA, thus dramatically facilitating the translation process.
| density | 1.576±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | >20 mg/mL in EtOH; >20.65 mg/mL in DMSO |
| pka | 9.43±0.10(Predicted) |
| form | A solid |
| color | White to off-white |
| Water Solubility | insoluble in Water; |
| Purity | 99% |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
N1-Methylpseudouridine is a substitute for uridine in modified mRNA. This substitution has shown to increase transfection by reducing immuogenicity. The 1-methylpseudouridine substituted mRNA increases protein expression due to low immune stimulation as it evades detection by the edosomal Toll-like receptor (TLR3).
N1-methylpseudouridine (m1Ψ), the modification used in the current mRNA SARS-CoV-2 vaccines, was found to possess superior characteristics to Ψ; m1Ψ elicited less immunogenicity and increased protein production by more than an order of magnitude relative to Ψ m1Ψ preserves the fidelity of tRNA selection by the ribosome. Kim et al. explored the effect of m1Ψ and Ψ on decoding using various in vitro systems.
N1-Methylpseudouridine is the methylated derivative of pseudouridine. It is used in in vitro transcription and for the production of RNA vaccines.In vertebrates, it stimulates significantly less activation of the innate immune response compared to uridine,while the translation is stronger.In protein biosynthesis, it is read like uridine and enables comparatively high protein yields.The nucleoside itself can be made by chemical methylation of pseudouridine.
CONTACT/Email address: Joy@coreychem.com
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