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Mexiletine hydrochloride

CAS NO.:5370-01-4

Appearance: White or almost white ,crystalline powder

Assay: 99.0%-101.0%

 

Product Name

Mexiletine hydrochloride

Common Name

1-(2,6-dimethylphenoxy)-2-aminopropanehydrochloride;1-(2,6-dimethylphenoxy)-2-propanaminhydrochloride;Ko 1173Cl;Mexilitene;1-(2,6-DIMETHYLPHENOXY)-2-PROPANANMINE HYDROCHLORIDE;MEXILETIN HYDROCHLORIDE;2-Propanamine, 1-(2,6-dimethylphenoxy)-, hydrochloride (9CI);Ethylamine, 1-methyl-2-(2,6-xylyloxy)-, hydrochloride (7CI, 8CI)

Chemical Formula

C11H18ClNO

Molecular Weight

215.72

CAS NO

318-98-9

Water

≤0.5%

Supply capacity

Ton level

Appearance

White or almost white ,crystalline powder

Assay 99.0%-101.0%

Lead time

In stock

Hs code

2922199090

Packing 

25kg/cardboard barrels

Contact Info

Nicole Zhao

Nicole@coreychem.com

Description Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or inhibits conduction across the Purkinje fiber-muscle junction, shortens action potential duration, and decreases the refractory period when used at concentrations less than 5 μg/ml in isolated canine Purkinje fiber and ventricular muscle preparations.
Chemical Properties White to Off-White Solid
Originator Mexitil,Boehringer Ingelheim,US,1976
Uses Antiarrhythmic (class IB)
Uses antipsychotic
Uses Mexiletine hydrochloride has been used as a sodium channel blocker:

  • expressed in chinese hamster ovary cells
  • in human embryonic kidney (HEK) cells for whole cell patch-clamp studies
  • electrophysiology studies in HEK cells expressing Nav1.7 protein

【Packaging Specifications】 Standard packaging: 25kg/ardboard barrels or according to the customer’s requirements

Contact Manager Email:Nicole@coreychem.com

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