Methylaminoacetaldehyde Dimethyl Acetal CAS 122-07-6

CAS NO.：122-07-6

Purity: ≥99.0%
Appearance: Colorless transparent liquid
Product Manager Email: emma@coreychem.com

Item	Details
Product Name	Methylaminoacetaldehyde Dimethyl Acetal
Synonym	2,2-Dimethoxy-N-methylethanamine; N-Methylaminoacetaldehyde dimethyl acetal
CAS NO.	122-07-6
Appearance	Colorless transparent liquid
Purity	≥99.0% (GC)
Molecular Formula (MF)	C₅H₁₃NO₂
Molecular Weight (MW)	119.16
EC Number	204-520-0
Density	0.928 g/mL (25 °C)
Refractive Index	n₂₀/D 1.414
Boiling Point	140 °C (760 mmHg)
Melting Point	-73 °C
Flash Point	29 °C
Solubility	Miscible with ethanol, methanol, dichloromethane and other organic solvents; slightly soluble in water
Related Categories	Organic Intermediates; Amine Compounds; Acetal Derivatives; Pharmaceutical Synthetic Building Blocks
Transport Information	Ordinary flammable liquid, general chemical transportation
HS Code	29225000
Product Manager Email	emma@coreychem.com

Frequently Asked Questions (FAQ)

Question 1: What is Methylaminoacetaldehyde Dimethyl Acetal (CAS 122-07-6)?

It is a typical bifunctional organic synthetic intermediate containing methylamino and dimethyl acetal groups. The acetal structure can be hydrolyzed to generate active aldehyde groups under acidic conditions, while the secondary amine group supports nucleophilic substitution and condensation reactions. It is widely used for the construction of nitrogen-containing heterocyclic compounds and drug molecular skeleton modification in fine chemical and pharmaceutical synthesis.

Question 2: What are its core physical and chemical characteristics and handling notes?

This product is a colorless transparent low-viscosity liquid with low boiling point and low flash point, belonging to flammable chemicals. It is stable under neutral and alkaline conditions but easily hydrolyzes in acidic environments to produce aldehyde impurities. Laboratory operation requires ventilated environment, away from open fire and high temperature; avoid contact with strong acid substances to prevent structural decomposition and purity decline.

Question 3: What are the main application fields of this product?

It is mainly applied in pharmaceutical intermediate synthesis, nitrogen heterocyclic compound construction and fine chemical derivation. It serves as a key raw material for the synthesis of thiamazole and other therapeutic drugs, and can also be used to prepare indolizine derivatives and amino acid analogues. Additionally, it is used for custom synthesis of special aliphatic amine intermediates in chemical research laboratories.

Question 4: What are the transportation and leakage emergency treatment measures?

Transport strictly follows flammable liquid specifications, avoiding high temperature exposure, open fire and violent shaking, and prohibits mixed transportation with strong acids and oxidants. In case of leakage, absorb the liquid with inert absorbent cotton or dry sand, collect waste materials for centralized processing, and do not rinse directly with water. For skin and eye contact, rinse continuously with clean water for several minutes to relieve irritation.

Question 5: What reaction conditions and reagents are commonly used to prepare downstream derivatives?

Under mild acidic catalysis, its acetal group hydrolyzes to generate methylaminoacetaldehyde, which can undergo cyclization reaction with sulfur-containing and nitrogen-containing reagents to prepare heterocyclic drug intermediates. The secondary amine group can perform alkylation and acylation reactions under weak alkaline conditions to generate various N-substituted aliphatic amine derivatives. Low-temperature and neutral reaction systems are recommended to avoid raw material decomposition.

Application 1: What core value does it have in pharmaceutical intermediate synthesis?

It is a critical raw material for the synthesis of multiple small-molecule therapeutic drugs. The most representative application is the preparation of methimazole, a classic drug for treating hyperthyroidism. By utilizing its unique amino and acetal bifunctional activity, it can complete efficient cyclization and structural remodeling, providing high-purity synthetic precursors for the mass production of thyroid regulating drugs with stable yield and low impurity content.

Application 2: What role does it play in heterocyclic compound synthesis?

As a nitrogen-containing aliphatic building block, it can react with pyridinium salts and other cyclic substrates to construct aza-cyclazine and indolizine derivative skeletons. These heterocyclic structures are core frameworks for many anti-inflammatory and antibacterial lead compounds. It effectively simplifies the multi-step synthesis process of complex nitrogen heterocycles and improves the synthesis efficiency of target molecules.

Application 3: Why can it optimize the synthesis quality of nitrogen-containing drug molecules?

Its bifunctional groups can be activated step by step under controllable conditions. The acetal group ensures stable storage and avoids premature oxidation and deterioration of aldehyde active groups, while the methylamino group provides fixed-site modification points. This controllable activation feature effectively reduces side reactions in drug synthesis, improves the purity and yield of pharmaceutical intermediates, and is more suitable for standardized pharmaceutical synthesis processes compared with ordinary amine monomers.

Application 4: What is its application in amino acid and bio-chemical derivation?

It can be used to synthesize substituted phenylglycine analogues through specific condensation reactions. These modified amino acid derivatives are important research tools for peptide drug modification and biological structure-activity relationship verification. It provides new structural options for the development of non-natural amino acid monomers and bioactive peptide molecules.

Application 5: Are its application scenarios limited to pharmaceutical synthesis?

No. It also has wide applications in fine chemical research and custom monomer synthesis. It can be used to prepare special aliphatic amine additives, organic synthesis raw materials for chemical reagent customization, and intermediate precursors for pesticide molecular modification. It is a versatile fine chemical building block covering medicine, biochemistry and fine chemical fields.

100g/bottle;
1kg/bottle;
25kg/drum;
Packaging according to customer requirements.

Product actual photos:

Storage & Transportation Requirements:

1. Store in tightly sealed container under cool, dry and ventilated environment; recommended long‑term storage temperature 2‑8 °C, avoid direct sunlight to slow down decomposition and eliminate elimination impurities.
2. Keep far away from strong‑base, strong‑oxidizer storage zones.
3. During transportation, avoid violent collision and high‑temperature exposure; do not mix with strong‑alkaline goods.
4. Shelf‑life under proper sealed cold‑storage condition: 12 months. Re‑inspect purity before use once stored for long time.

For further information about the product, please contact:
Product Manager Email: emma@coreychem.com

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Methylaminoacetaldehyde Dimethyl Acetal CAS 122-07-6

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