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White to slightly beige powder MF: C9H11IN2O5 MW: 354.1
Synonyms: 5-Indo-2ˊ-deoxyuridine;1-beta-d-2’-deoxyribofuranosyl-5-iodouracil;1beta-D-2′-Deoxyribofuranosyl-5-iodouracil;2’-deoxy-5-iodo-uridin;5-Iodouracil deoxyriboside;5-iodouracildeoxyriboside; 5-IUdR
Product Categories: Heterocyclic Compounds;Amino Acids;Antivirals for Research and Experimental Use;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents; Nucleotides;Pharmaceuticals;CYTOVENE;Nucleosides-5-I Nucleosides
| Melting point | 194 °C (lit.) |
| alpha | 280 º (c=1,1M NaOH) |
| density | 1.7911 (estimate) |
| refractive index | 30 ° (C=1, 1mol/L NaOH) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated) |
| form | Crystalline Powder |
| pka | 8.25(at 25℃) |
| color | White to slightly beige |
| biological source | synthetic (organic) |
| Optical Rotation | 28.4189°(C=0.8943g/100ml NAOH) |
| Water Solubility | 1.6 g/L (20 ºC) |
| Sensitive | Air & Light Sensitive |
| Purity | 99% |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
5-Iodo-2′-deoxyuridine is a nucleoside analog that inhibits the replication of viruses and other DNA-containing organisms. 2′-Deoxy-5-iodouridine also has inhibitory properties on cell nuclei, which may be due to its ability to bind with DNA and prevent the synthesis of RNA or protein.
Idoxuridine is an antiviral agent effective against herpes-simplex infections; in ophthalmie eyedrops, ointments, and solutions.5-Iodo-2′-deoxyuridine is antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents.Idoxuridine (Herplex) is a water-soluble iodinated derivative of deoxyuridine that inhibits several DNA viruses including HSV, VZV, vaccinia, and polyoma virus.
5-Iodo-2′-deoxyuridine prevents in vitro DNA viral replication. This is observed in herpesviruses and poxviruses It might possess teratogenic, tumor-promoting, mutagenic, and immunosuppressive properties. 5-Iodo-2′-deoxyuridine, used in topical applications, is effective against epithelial infections.
CONTACT/Email address: Joy@coreychem.com
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