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White solid MF: C8H8O3 MW: 152.15
Synonyms: HMBA;HMBA LINKER;4-CARBOXYBENZYL ALCOHOL;4-HYDROXYMETHYLBENZOIC ACID;HMBA LINKER,4-HYDROXYTHYLBENZOIC ACID;Hydroxymethylbenzoicacid;
Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids;Linkers for Solid Phase Synthesis;Combinatorial Chemistry;Linkers;Synthetic Organic Chemistry;Biochemics;Bifunctional CrosslinkersCarbonyl Compounds;C8;Carboxylic Acids;Peptide Synthesis
| Melting point | 182-185 °C (lit.) |
| Boiling point | 140-150 °C(Press: 9 Torr) |
| density | 1.314±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| pka | 4.16±0.10(Predicted) |
| form | solid |
| color | White |
| Purity | 99% |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
4-(Hydroxymethyl)benzoic Acid is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive age nt.
This linkage reagent for SPPS is essentially acid stable. It is useful in combination with Fmoc-amino acids. Its peptide esters are usually cleaved by basic or nucleophilic reagents, especially by ammonia in the preparation of peptide amides.
4-(Hydroxymethyl)benzoic Acid (Eprosartan USP Related Compound E) is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive agent.
CONTACT/Email address: Joy@coreychem.com
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