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H-Ser(tBu)-NH2.HCI-cas-no-323587-47-9

H-Ser(tBu)-NH2.HCI

CAS NO.:323587-47-9

Purity : 99%
Appearance: White to off white solid powder

Product Name H-Ser(tBu)-NH2.HCI
Synonyms (2S)-2-Amino-3-(tert-butoxy)propanamidehydrochloride;H-Ser(tB)-NH2·HCl;amino(2S)-2-amino-3-(tert-butoxy)propanoatehydrochloride;H-L-ChemicalbookSer(tBu)-NH2HCl;O-(2-Methyl-2-propanyl)-L-serinamidehydrochloride(1:1);H-Ser(tBu)-NH2.HCI;Ser(tbu)-NH2.HCL;O-tert-Butyl-L-serinamide
CAS NO 323587-47-9
Appearance White to off white solid powder
Purity 99%
MF C7H17ClN2O2
MW 196.68
Contact selina@coreychem.com

H-Ser(tBu)-NH₂·HCl (CAS: 323587-47-9) is a protected serine derivative commonly used in solid-phase peptide synthesis (SPPS). In this compound:

  • The hydroxyl group is protected with a tert-butyl (tBu) group to prevent side reactions during synthesis.

  • The carboxyl group is amidated (–NH₂), making it ideal for synthesizing peptides with C-terminal amide structures.

  • The hydrochloride salt form enhances stability and solubility.

This compound is widely used in the synthesis of C-terminal amidated peptides, including therapeutic peptides, bioactive peptides, and vaccine candidates. The tBu group can be removed under acidic conditions (e.g., TFA) during final deprotection to regenerate the free hydroxyl group.

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