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White powder MF: C20H31N5O10 MW: 501.49 Synonyms: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester;DOTA-NHS-ester(B-280);DOTA mono-N-hydroxysuccinimide ester; DOTA (dodecane tetraacetic acid, also known as tetraxetan) is a complexing agent, especially for lanthanide ions. DOTA-NHS ester is a bifunctional linker containing chelating and N-hydroxysuccinimide (NHS) ester groups for conjugation with amine-containing biomolecules. ***The salt form is more stable. *** Could be supplied at 50KG up to larger quantity.
| Boiling point | 743.7±70.0 °C(Predicted) |
| density | 1.51±0.1 g/cm3(Predicted) |
| storage temp. | -20°C, sealed storage, away from moisture |
| solubility | DMSO: 50 mg/mL (99.70 mM) |
| pka | 2.46±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| Appearance | white powder |
| Purity | 95% |
| Product manager | Joy Wu; Email:Joy@coreychem.com |
DOTA (dodecane tetraacetic acid, also known as tetraxetan) is a complexing agent, especially for lanthanide ions.
DOTA-NHS ester is a bifunctional linker containing chelating and N-hydroxysuccinimide (NHS) ester groups for conjugation with amine-containing biomolecules.
CONTACT/Email:Joy@coreychem.com
DOTA and NOTA are important intermediates for the synthesis of diagnostic reagents and therapeutic drugs.
Radioactive metal elements need to be labeled through bifunctional chelating agents such as DOTA and NOTA molecules, which is currently a commonly used labeling method for PD-1/PD-L1 targeted radionuclide
probes. Especially in the manufacture of contrast agents for medical imaging techniques such as magnetic resonance imaging (MRI), X-ray CT, and ultrasound imaging, as well as in the development of
radioactive therapeutic drugs for malignant tumors, DOTA, NOTA and their derivatives have shown extremely important application value.
1kg,5kg in Aluminium foil Bag; 10kg,20kg,25kg in Fiber Can; Keep Sealed and Dry, at low temperature Packing according to requirements. ***Shipped by courier ( FEDEX,DHL), by Air flight,By sea. ***The forwarder is our long-term cooperated agent with professional experience for intermational transportation. ***We also could assistant with customs clearance and documents.
