Main Functions of DLin-KC2-DMA (CAS: 1190197-97-7)

DLin-KC2-DMA is an ionizable lipid primarily used for formulating lipid nanoparticles (LNPs) designed for nucleic acid delivery, especially mRNA, siRNA, and DNA.

1. Core Ionizable Lipid in LNP Systems

DLin-KC2-DMA becomes positively charged under acidic conditions and binds to the negatively charged phosphate backbone of nucleic acids, enabling efficient encapsulation and stable nanoparticle formation.

2. Enhances Delivery of mRNA and siRNA

This lipid exhibits strong endosomal escape capability, allowing nucleic acids to be released into the cytoplasm after cellular uptake, thereby improving biological activity.

3. Used in mRNA Vaccines and Gene Therapy

DLin-KC2-DMA is widely applied in research involving:

• mRNA vaccine platforms

• siRNA delivery systems

• Gene-editing tools (e.g., CRISPR mRNA + gRNA)

• Cancer immunotherapy

• RNA-based therapeutics for rare diseases

4. Alternative to Classic Ionizable Lipids (e.g., DLin-MC3-DMA)

It offers high delivery efficiency and lower toxicity, making it a commonly used ionizable lipid in early and current LNP research.