- +86 0371-86658258
- info@coreychem.com
English
MF: C26H24N2O4 MW: 428.48
Synonyms: (1R,2R)-2-[[4′-[[(Phenylamino)carbonyl]amino][1,1′-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid;DGAT-1 inhibitor;Diacyl glycerolacyltransferase 1 inhibitor;A922500;A922500(DGAT-1 Inhibitor 4a);enylureido)biphenyl(1R,2R)-2-(4′-(3-phcarbonyl)cyclopentanecarboxylic acid; (1R,2R)-2-(4′-(3-phenylureido)biphenylcarbonyl)cyclopentanecarboxylic acid
| density | 1.323 |
| storage temp. | -20°C |
| solubility | ≥21.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | Light yellow solid |
| color | light yellow |
| biological source | synthetic (organic) |
| Purity | 98% |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages. Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC 50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo . Orally active.
The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.
CONTACT/Email address: Joy@coreychem.com
1kg,5kg in Bag or bottle;10kg,20kg,25kg in Fiber Can; Packing according to requirements.
Shipped by courier ( FEDEX,DHL), by Air flight
The forwarder is our long-term cooperated agent with professional experience for intermational transportation.
We also could assistant with customs clearance and documents.
