Berberine hydrochloride

Berberine Hydrochloride (CAS 633-65-8) is the hydrochloride salt form of berberine, an isoquinoline alkaloid extracted from plants such as Coptis chinensis (goldthread), Phellodendron amurense (Amur cork tree), and others. It is widely used in pharmaceuticals, dietary supplements, and scientific research.

Main Functions:

1. Antimicrobial and Anti-inflammatory

• Effective against Gram-positive bacteria, Gram-negative bacteria, fungi, and protozoa.

• Clinically used for bacterial dysentery, enteritis, and urinary tract infections.

2. Blood Glucose Regulation & Metabolic Improvement

• Activates the AMPK (adenosine monophosphate-activated protein kinase) pathway, enhancing glucose metabolism.

• Supports type 2 diabetes management by lowering blood glucose and improving insulin resistance.

3. Lipid-lowering & Cardiovascular Protection

• Reduces total cholesterol, triglycerides, and LDL cholesterol.

• Shows potential benefits in atherosclerosis prevention and anti-arrhythmic effects.

4. Antioxidant & Anti-aging

• Reduces oxidative stress and suppresses inflammatory cytokines.

5. Antitumor Potential

• Research indicates inhibitory effects on tumor cell proliferation and induction of apoptosis.

6. Other Functions

• Helps regulate gut microbiota and supports digestive health.

• Exhibits neuroprotective and antidepressant-like effects in preclinical studies.