Benfotiamine

Product Applications

Phenylthioanthranilic acid is a lipid-soluble derivative of thiamine. It has a higher bioavailability than thiamine. However, phenylthioanthranilic acid must be dephosphorylated by alkaline phosphatase into a lipid-soluble precursor before it can cross the cell membrane and exert its biological effects.
Clinically, it is mainly used for the treatment of diabetic complications, especially Chemicalbook for the treatment and prevention of diabetic retinopathy.

Compared with other derivatives of thiamine, this product is absorbed more rapidly and completely after oral administration. Phosphoryl thiamine is rapidly metabolized into thiamine after entering the systemic circulation but does not increase the drug concentration in the brain. At the same time, it generates hippuric acid and is excreted through urine.