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Colorless to light yellow liquid MF: C48H95NO5 MW: 766.27
Synonyms: Decanoic acid, 2-hexyl-, 1,1′-[[(4-hydroxybutyl)imino]di-6,1-hexanediyl] ester;((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate);6-[6-(2-hexyldecanoyloxy)hexyl-(4-hydroxybutyl)amino]hexyl 2-hexyldecanoate;Lipid ALC-0315;((4-hydroxybutyl) azanediyl) bis (hexane-6,1-diyl) bis (2-hexyldecanoate);6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1-aminium
ALC-0315 ([(4-hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate)) is a synthetic lipid. A colorless oily material, it has attracted attention as a component of the SARS-CoV-2 vaccine.
| Boiling point | 760.6±55.0 °C(Predicted) |
| density | 0.919±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C, protect from light |
| solubility | Soluble in Ethanol, DMSO, DMF |
| pka | 15.11±0.10(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
| Purity | 99% |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
ALC-0315 is one of the components of the BNT162b2 vaccine (0.43 mg per dose). Its chemical properties as a tertiary amine mean that its cation can form an ionic bond to the messenger RNA which carries the genetic information for the SARS-CoV-2 spike protein formation in the human body. Importantly, once the lipid nanoparticle which encapsulates the mRNA has been absorbed into antigen-presenting cells (a process called receptor-mediated endocytosis) the more acidic environment within the endosome fully protonates the ALC-0315 as a result the nanoparticle releases its payload of mRNA.
ALC-0315 is a cationic lipid and is critical to the self-assembly process of the particle itself, the ability of the particle to be taken up into cells and the escape of the RNA from the endosome.
ALC-0315 is the functional cationic lipid component of the drug product. When incorporated in lipid nanoparticles, it helps regulate the endosomal release of the RNA.
CONTACT/Email address: Joy@coreychem.com
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