- +86 0371-86658258
- info@coreychem.com
English
Purity: 95% | Packaging information: 1g; 10g; 100g
Advantageous products, welcome to consult: selina@coreychem.com
| Product Name | ALC-0159 |
| Synonyms | Methoxypoly(ethyleneglycol)ditetradecylacetamide;2-[(polyethyleneglycol)-2000]-N,Nditetradecylacetamide(ALC-0159);Poly(oxy-1,2-ethanediyl),α-[2-(ditetradecylamino)-2-oxoethyl]-ω-methoxy-;2-(2-methoxyethoxy)-N,N-ditetradecylacetamide,ammoniasalt;LipidALC-0159;mPEG-DTA;α-[2-(Ditetradecylamino)-2-oxoethyl]-ω-methoxy-Poly(oxy-1,2-ethanediyl);ALC0159,conjugate,lipid,vaccine,ALC0159,ALC-0159,inhibit,excipient,Inhibitor |
| CAS NO | 1849616-42-7 |
| Purity | 98% |
| Appearance | off-white to white silid |
| MF | C44H81NO2 |
| MW | 656.12 |
| Contact | selina@coreychem.com |
ALC-0159 (CAS: 1849616‑42‑7) is a PEGylated lipid (PEG-lipid) widely used in biopharmaceutical applications, especially in mRNA vaccines and lipid nanoparticle (LNP) formulations. Its main functions are:
Stabilizing Lipid Nanoparticles (LNPs)
The PEG chain of ALC-0159 attaches to the surface of lipids, providing steric hindrance that prevents nanoparticle aggregation.
It enhances the stability and shelf-life of LNPs in solution.
Prolonging Circulation Time / Reducing Immune Clearance
The PEG coating reduces protein adsorption (protein corona formation) in the bloodstream, thereby extending the circulation time of lipid nanoparticles.
This helps improve the in vivo delivery efficiency of drugs or mRNA.
Modulating Nanoparticle Surface Properties
By forming a PEG layer on the LNP surface, ALC-0159 improves particle uniformity and reduces nonspecific adsorption and toxicity.
It is typically used in combination with cationic lipids (e.g., ALC-0315), cholesterol, and DSPC in mRNA vaccine formulations.
In summary: ALC-0159 primarily acts as a PEGylated lipid stabilizer, protecting and modulating lipid nanoparticles to enhance their in vivo delivery efficiency and safety.
Contact us for more information: selina@coreychem.com
50mg;100mg;250mg;500mg;1g;5g
Or package according to customer needs.
![CAS no 57626 36 5 Imidazo[2,1 b][1,3]thiazol 6 ylacetic acid hydrochloride hydrate](https://www.coreychem.com/wp-content/uploads/2026/03/CAS-no-57626-36-5-Imidazo21-b13thiazol-6-ylacetic-acid-hydrochloride-hydrate.jpg)
![CAS NO 1800075 46 0 1,3 Dioxolan 2 one, 4 [(1,3,2 dioxaphospholan 2 yloxy)methyl]](https://www.coreychem.com/wp-content/uploads/2026/03/CAS-NO-1800075-46-0-13-Dioxolan-2-one-4-132-dioxaphospholan-2-yloxymethyl.jpg)
