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Yellow solid MF: C15H10O4 MW: 254.24
Synonyms: 7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4-benzopyrone;DIHYDROXYFLAVONE, 7,8-(RG);7,8-Dihydroxyflavone hydrate;7,8-dihydroxy-2-phenyl-1-benzopyran-4-one;8-Dihydroxyflavone;7,8-DIHYDROXYFLAVONE
Product Categories: Inhibitors;Biochemistry;Di-substituted Flavones;Flavonoids;pharmaceutical;BPC;plant extract
7,8-Dihydroxyflavone(7,8-DHF) is a naturally occurring flavone found in the tree Godmania aesculifolia. It is a selective tyrosine kinase receptor B(TrkB) agonist that has neurotrophic effects in various neurological diseases such as stroke and Parkinson’s disease.
| Melting point | 243-246°C |
| Boiling point | 494.4±45.0 °C(Predicted) |
| density | 1.443±0.06 g/cm3(Predicted) |
| FEMA | 4830 | 7,8-DIHYDROXYFLAVONE |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO: soluble24mg/mL |
| form | solid |
| pka | 6.86±0.40(Predicted) |
| color | Yellow or tan |
| Stability: | Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week. |
| Purity | 99% |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
7,8-Dihydroxyflavone is disubstituted flavone that acts as a small-molecule TrkB agonist. 7,8-Dihydroxyflavone has been shown to reverse memory deficits and BACE1 elevation in a mouse model of Alzheimer”s disease. 7,8-Dihydroxyflavone may also provide a therapeutic option in the treatment of other neorological disorders such as Rett syndrome and PTSD. It has recently been shown to counteract the inhibition of NMDA receptor caused by lead poisoning and confer protective effects in live rats.
7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.
CONTACT/Email address: Joy@coreychem.com
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