Home » Products » Pharmaceuticals » 6-Maleimidocaproic acid-NHS (EMCS) CAS-no-55750-63-5
MF: C14H16N2O6 MW: 308.29
Synonyms: Mal-heptanoic NHS ester;EMCS N-Succinimidyl 6-maleimidohexanoate;(2,5-Dioxopyrrolidin-1-yl) 6-(2,5-dioxopyrrol-1-yl)hexanoate;6-Maleimidohexanoic acidN-hydroxysuccinimide ester≥ 98% (HPLC);N-(E-MALEIMIDOCAPROYLOXY)SUCCINIMIDE;N-(EPSILON-MALEIMIDOCAPROYLOXY)SUCCINIMIDE;N-[EPSILON-MALEIMIDOCAPROYLOXY]SUCCINIMIDE ESTER;
Product Categories: Building Blocks;Carbonyl Compounds;N-Substituted Maleimides;Chemical Synthesis;Cyclic Imides;Organic Building Blocks;N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Succinimides;i;Heterobifunctional Crosslinker;heteroXlink
| Melting point | 70-73 °C(lit.) |
| Boiling point | 480.6±47.0 °C(Predicted) |
| density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | chloroform: 100mg/mL |
| form | powder |
| pka | -2.21±0.20(Predicted) |
| color | Off-white to pale brown |
| Sensitive | Light & Moisture Sensitive & Hygroscopic |
| Purity | 98% |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
Mal-heptanoic NHS ester contains a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
6-Maleimidohexanoic acid N-hydroxysuccinimide ester can be used in:
–Synthesis of maleimide-activated carbohydrates for site-specific glycosylation of cysteine-containing peptides and proteins via maleimide-thiol ligation reaction.
–Synthesis of a glucuronide prodrug of doxorubicin bearing a maleimide side chain as an antitumor agent.
–Cross-linking oligonucleotides with the amino groups on the substrate to fabricate DNA microarrays.
CONTACT/Email address: Joy@coreychem.com
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