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Yellow to orange solid MF: C21H12O7 MW: 376.32
Synonyms: Carboxyfluorescein;3′,6′-dihydroxy-1-keto-spiro[isobenzofuran-3,9′-xanthene]-5-carboxylic acid; 3′,6′-dihydroxy-1-oxospiro[2-benzofuran-3,9′-xanthene]-5-carboxylic acid;6-Carboxyfluorescein,6-FAM, FLUOS;6-Carboxyfluorescein Hydrate;6-FAM, 6-CF
Product Categories: marker;Fluorescent Labels and Indicators;Electronic Chemicals;Fluorescent Labels & Indicators;Fluorescent;Xanthene;FLUOROPHORES;FAM
| Melting point | >300 °C(lit.) |
| Boiling point | 736.4±60.0 °C(Predicted) |
| density | 1.73±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: soluble |
| form | Solid |
| pka | 3.3, 4.6, 6.4, 7.0(at 25℃) |
| color | Yellow to orange |
| PH Range | Weak green ‘ uorescence (6.0) to strong green ‘ uourescence (7.2) |
| Purity | 99% |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
6-Carboxyfluorescein (6-FAM) is derivative of fluorescein giving stable derivative upon conjugation with biopolymers.It has been used to check the plasma membrane integrity in sperm cells. The single isomer, 6-FAM, contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid. Commercially available FAM is a mixture of two isomers, 5-FAM and 6-FAM, and the correct name is 5(6)-carboxyfluorescein. 6-Carboxyfluorescein diacetate is a membrane permeable compound. It can be hydrolysed by intracellular esterases to form a membrane impermeable bright green fluorescent molecule, 6-carboxyfluorescein.
6-Carboxyfluorescein is a useful reagent for the preparation of hydrolytically stable fluorescent conjugates and is a useful starting material for the synthesis of other fluorescein-derives reagent. Fluorescein is the most common fluorescent derivatization reagent for labeling biomolecules. In addition to its relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility, fluorescein has an excitation maximum that closely matches the 488 nm spectral line of the argon-ion laser.
CONTACT/Email address: Joy@coreychem.com
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