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Off-white powder MF: C5H3FN2O4 MW: 174.09
Synonyms: 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicaci; 5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate;2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid;5-FLUOROURACIL-4-CARBOXYLIC ACID;5′ FOA
Product Categories: pyrimidine;Fluorine series;Nucleotides and Nucleosides;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;5-FOA;Bases & Related Reagents;Nucleotides;Aromatic Halides (substituted)
| Melting point | 278 °C (dec.)(lit.) |
| Boiling point | 143°C (rough estimate) |
| density | 1.6154 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | NH4OH 4 M: 50 mg/mL, clear, faintly yellow |
| pka | 2.04±0.20(Predicted) |
| form | solid |
| color | Pale yellow |
| Purity | 98% |
| Product manager | Joy WU; Email:Joy@coreychem.com |
5-FOA(5-Fluoroorotic acid ) has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5′-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis.
More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.
CONTACT/Email address: Joy@coreychem.com
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