3-SULFOPROPYLDIMETHYL-3-METHACRYLAMIDOPROPYLAMMONIUM INNER SALT

📄1.Basic Product Properties
Chemical Name: 3-[(Methacrylamido)propyl]dimethyl(3-thiopropyl)ammonium hydroxide inner salt

Common Name/Abbreviation: An acrylamide derivative of SPP or SBMA. It is a structural analog of the zwitterionic monomer sulfo-betain acrylate, but replaces the ester bond (-COO-) with a more stable amide bond (-CONH-).

Molecular Structure Features: Contains both:

Polymerizable group: Methacryloyl group, suitable for free-radical polymerization.

Strong hydrophilic/amphoteric group: Sulfosuccinate group (quaternary ammonium cation + sulfonate anion).

Connecting chain: Flexible propyl chain.

📌2.Core Features and Advantages
All advantages of this compound stem from the combination of its “amphoteric betaine structure” and “polymerizable methacrylamide groups.”

1. Exceptional Resistance to Non-Specific Protein Adsorption and Biocompatibility
“Zero” Interfacial Free Energy: Its molecules possess strictly equal positive and negative charges in extremely close proximity. Through strong ion-dipole interactions with water molecules, they form a highly ordered “hydration layer.” This dense hydration layer creates a physical and energetic barrier.

Advantage: When this monomer is polymerized onto material surfaces (e.g., medical devices, contact lenses, biosensor chips), it significantly reduces the adhesion of blood, proteins, and bacteria. This core, most valuable property makes it irreplaceable in the field of anti-biofouling.

2. Environmental Responsiveness—The “Anti-Polyelectrolyte Effect”
Unique Phenomenon: Conventional polyelectrolytes (e.g., polycations) contract in salt solutions due to charge shielding. In contrast, polysulfobetaines (like this monomer polymer) exhibit the “anti-polyelectrolyte effect”: their segments become more extended in salt solutions, potentially increasing solution viscosity.

Advantage: Maintains superior hydration and lubrication properties in high ionic strength environments like saline or seawater, broadening application scenarios.

3. Exceptional Hydrophilicity and Lubricity
Strong Hydration Capacity: Charged groups bind large numbers of water molecules, forming a hydrogel-like surface.

Advantages: Endows coating materials with enduring hydrophilicity, anti-fogging, and lubricating friction-reducing properties. When applied to catheters, guidewires, and interventional devices, it significantly reduces insertion resistance, enhances patient comfort, and minimizes tissue damage.

4. Chemical and Hydrolytic Stability
Key Advantages (Compared to SBMA Ester Monomers): This monomer employs an amide bond (-CONH-) to link the polymeric segment to the betaine moiety, rather than the ester bond (-COO-) commonly used in SBMA.

Ester Bonds: Prone to hydrolysis under acidic, alkaline, or enzymatic conditions in vivo, leading to coating failure.

Amide Bonds: Exceptionally stable against chemical and enzymatic degradation, ensuring sustained coating performance under prolonged use or harsh environments. This represents the primary advantage over ester monomers like CAS 54182-57-9 (SBMA).

5. Polymerizability and Copolymerization Flexibility
Methylacrylamide group: Moderately reactive, readily copolymerizes with various other monomers (e.g., methyl methacrylate MMA, acrylamide, hydrophobic monomers) via conventional free-radical polymerization, RAFT, ATRP, etc.

Advantages: Facilitates the introduction of zwitterionic properties onto various polymeric substrates (plastics, rubber, metals, fibers) through graft copolymerization or blend modification, enabling tailored surface performance.

📊 ⭐ Why Choose Us

• Reliable supply for research and commercial quantities

• Strict quality control and batch consistency

• Experience with export compliance and documentation

• Support for custom synthesis and technical consultation

📩 Contact Information

For pricing, samples, technical data, or customized specifications, please contact:

●Product Manager:Lucy Yao

Email:  lucy@coreychem.com