|
Item
|
Details
|
|
Product Name
|
3-Hydroxy-4-methoxycinnamic acid
|
|
Synonym
|
Isoferulic acid; 3-Hydroxy-4-methoxycinnamate
|
|
CAS NO.
|
537-73-5
|
|
Appearance
|
White crystalline powder
|
|
Purity
|
≥98% (HPLC)
|
|
Molecular Formula (MF)
|
C₁₀H₁₀O₄
|
|
Molecular Weight (MW)
|
194.18
|
|
Density
|
1.316 g/cm³ (25 °C)
|
|
Boiling Point
|
410.2 °C at 760 mmHg
|
|
Melting Point
|
230 °C (dec.)
|
|
Flash Point
|
167.6 °C
|
|
Refractive Index
|
1.5168 (estimated)
|
|
Solubility
|
Soluble in methanol, ethanol, DMSO and ether; slightly soluble in cold water; insoluble in chloroform, benzene and petroleum ether
|
|
Related Categories
|
Cinnamic acid derivatives; Phenolic compounds; Natural plant metabolites; Pharmaceutical intermediates; Antioxidant raw materials
|
|
Transport Information
|
Non-dangerous goods, general chemical transport
|
|
HS Code
|
2918990090
|
|
MDL Number
|
MFCD00004391
|
|
Product Manager Email
|
emma@coreychem.com
|
Frequently Asked Questions (FAQ)
Question 1: What is 3-Hydroxy-4-methoxycinnamic acid (CAS 537-73-5)?
3-Hydroxy-4-methoxycinnamic acid, also known as isoferulic acid, is a natural active cinnamic acid derivative extracted and synthesized from various plants such as Salvia miltiorrhiza and Cimicifuga. It has a unique phenolic hydroxyl and methoxy bifunctional substituted aromatic structure, with excellent biological activity and chemical modifiability. It is widely used in biomedical research, cosmetic additives and fine chemical intermediate preparation.
Question 2: What are its key properties and daily operation precautions?
This product is white crystalline powder, thermally unstable at high temperature and decomposes at 230 °C. It has strong antioxidant activity and is sensitive to strong light and high temperature, which may cause color darkening and activity attenuation. During operation, avoid long-term light exposure and high-temperature heating. Wear dust-proof gloves and goggles to prevent inhalation and skin contact.
Question 3: What core application fields does this product cover?
It is mainly used in biomedical active research, natural antioxidant development, cosmetic functional additives and pharmaceutical intermediate synthesis. It possesses multiple biological activities including anti-oxidation, anti-glycosylation, hypoglycemic and antiviral effects, and is commonly used for new drug target screening, skin care raw material development and plant metabolite standard preparation.
Question 4: What are the transportation and emergency disposal guidelines?
It belongs to ordinary non-dangerous solid chemicals, suitable for normal temperature transportation. Keep packages sealed, avoid dampness, strong light and high-temperature stacking. In case of powder leakage, collect dry powder with clean tools and avoid dust flying. If contacted with skin or eyes, rinse thoroughly with running water; seek medical treatment in case of persistent discomfort.
Question 5: How to synthesize and derivatize downstream products based on this compound?
The carboxyl group can undergo esterification and amidation reactions to prepare cinnamic acid ester derivatives. The phenolic hydroxyl group can be modified by alkylation and acylation to generate high-activity functional derivatives. It can also be used as a raw material for structural optimization of antioxidant and hypoglycemic lead compounds, providing diversified precursor molecules for pharmaceutical and cosmetic derivation.
