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Synonyms: (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(10R,12S,13R,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;GINSENOSIDE RG3(R-FORM)(P);Ginsenoside Rg3 (R-);Ginsenoside Rg3 Rh2;20(R)Ginsenoside Rg3 20(R);20(r)-propanaxadiol
MF: C42H72O13 MW: 785.01
Product Categories: Ginsenoside series;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
| Melting point | 315-318 ºC |
| Boiling point | 885.0±65.0 °C(Predicted) |
| density | 1.30 |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Very Slightly, Heated Sonicated), Pyridine (Slightly, Heated, Sonicated) |
| Purity | 98% |
| form | Solid |
| color | White to Off-White |
| Stability: | Hygroscopic |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
20(R)-Ginsenoside Rg3 causes an inhibition of phosphatidylinositol 3-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of U87 cells are regulated. Elicits a significant inhibition of in vitro cell adhesion and invasion of U87 cells. in vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase isoforms and in vivo inhibition of tumor angiogenesis of lung cancer.
Ginsenoside Rg3 is a tetracyclic triterpenoid saponin type rich in red ginseng. The major ginsenosides, such as Rb1, Rb2, and Rg3. Due to the different spatial structures from C20 positions, there are two enantiomers, 20(R) and 20(S)-isomers. With differential conguration, their antitumor activities exhibit certain differences. 20(R)-ginsenoside Rg3 and 20(S)-ginsenoside Rg3 can inhibit tumor metastasis by the suppression of EMT. 20(R)-ginsenoside Rg3 suppressed lung cancer migration or/and invasion by inhib-iting TGF-β1-induced EMT accompanied by the inactivation of MMP-2, p38 MAPK and Smad2. In addition, 20(S)-ginsenoside Rg3 effectively suppressed hypoxia-induced EMT, inhibiting ovarian cancer metastasis.
CONTACT/Email address: Joy@coreychem.com
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