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Purity: ≥95%
Appearance: Light yellow to light brown Solid-liquid mixture
Product Manager Email: crystal@coreychem.com
| Product Name: | 2-methoxy-4-(trifluoromethyloxy)phenol |
| Synonyms: | 2-methoxy-4-(trifluoromethyloxy)phenol;2-methoxy-4-(trifluoromethoxy)phenol;Phenol, 2-methoxy-4-(trifluoromethoxy) |
| CAS: | 166312-49-8 |
| MF: | C8H7F3O3 |
| MW: | 208.13 |
| Boiling point | 224.0±35.0 °C(Predicted) |
| density | 1.366±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C, stored under nitrogen |
| pka | 9.36±0.18(Predicted) |
| Appearance | Light yellow to light brown Solid-liquid mixture |
| HS code | 2909500000 |
| Transport Information | Non-hazardous goods |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
Frequently Asked Questions：
1.What is the main purpose of 2-methoxy-4-(trifluoromethyloxy)phenol?
As a fluorinated pharmaceutical building block, the OCF₃ group enhances metabolic stability, lipophilicity, and blood-brain barrier penetration. As a synthetic intermediate, it undergoes further transformation via the phenolic hydroxyl or methoxy group to build active molecules. In pesticides, OCF₃ improves environmental stability and bioactivity. In materials/electronic chemicals, fluorinated aromatic phenols serve as modifying monomers for polyimides, polycarbonates, and epoxy resins.
2.What are the features of the product?
‑ Phenolic hydroxyl (1‑OH): Supports direct O‑alkylation, O‑acylation and esterification; conversion to triflate offers a versatile reaction handle for Suzuki, Buchwald‑Hartwig and other cross‑couplings.
‑ Trifluoromethoxy (‑OCF₃): Core functional group. Strong electron‑withdrawing effect and high lipophilicity improve metabolic stability, membrane permeability and target‑binding affinity. It is a privileged fluorinated substituent in medicinal chemistry (alongside ‑CF₃, ‑SCF₃).
‑ Ortho‑OMe: Delivers unique electronic‑conformational properties to the guaiacol skeleton and enables regioselective aromatic‑ring modification.
3. How difficult is its synthesis?
The introduction of the ‑OCF₃ group has long been a well‑known synthetic challenge. Overall, the synthesis is moderately difficult, yet this hurdle has been overcome. It falls into the category of “known process but costly upon scale‑up”.
4.How to storage?
For long‑term storage, refrigerate at 2‑8 °C; for short‑term storage, keep in a cool, dry and tightly‑sealed environment. Since phenols are prone to oxidation and darkening upon exposure to air, protection with an inert gas is required
5. What can Career Henan Chemical Co. do?
This is a low‑volume, high‑value‑added fluorinated fine chemical for research use as a synthetic building block. No stock is maintained; synthesis is custom‑run per order. Our proven production process allows customized specifications, and pricing can be negotiated.
Application 1: Pharmaceutical intermediates (the primary potential application direction)
Function: As a pharmaceutical molecular building block for the construction of drug‑candidate molecules; the ‑OCF₃ group is utilized to optimize metabolic stability of drugs and improve oral bioavailability.
Sub‑segments:
① Candidate drugs for the central nervous system (synthesis of benzoxazine‑ and benzofuran‑type skeletons; research on 5‑HT receptor modulators, analogous to lead‑structure modification of numerous methoxyphenol leads);
② Small‑molecule anti‑inflammatory agents and kinase inhibitors;
③ Antimicrobial lead compounds (modification of quinazoline and quinoline parent cores via fluorinated phenolic ether structures).
Note: At present, no marketed drug directly adopts this compound as a starting material. It is mainly applied in lab‑scale synthesis during the new‑drug research and development phase.
Application 2. Agrochemical and agricultural‑chemical intermediates (promising field)
Function: Synthesis of lead molecules for fluorinated aromatic‑ring fungicides and insecticides.
The trifluoromethoxy group is a frequently‑used privileged moiety in modern agrochemicals. Many novel quinoline and aryl‑ether insecticides employ similar skeletons. Its phenolic hydroxyl group enables the construction of aryl ether linkages for the synthesis of candidate compounds targeting pest G‑protein‑coupled receptors.
Current status: It remains at the laboratory screening stage, and no industrialized agrochemical product has been developed.
Application3. Liquid‑crystal and optoelectronic functional materials (potential application direction)
Function: Used for synthesizing precursors of aryl‑ether‑based liquid‑crystal monomers; the ‑OCF₃ group can adjust the dielectric anisotropy of liquid‑crystal molecules.
It can also be adopted to prepare special aromatic monomers for modifying high‑performance polyarylether resins, lowering the dielectric constant of resins for high‑frequency electronic substrates.
Limitation: This molecule itself is not a liquid crystal and can only serve as a starting raw material for the synthesis of monomers.
Transport Information: Non-hazardous goods
Packing size:
Sample: Sample: brown glass bottle
1kg: Bottle
Storage temp：
Keep in dark place, Store sealed under refrigeration at 2‑8 °C
Expiration date：
About 12 months if properly stored
Contact person:Crystal@coreychem.com
Website: www.coreychem.com
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