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| Product name | 2-IMINOTHIOLANE |
| Synonym |
Nsc340007;2-Iminothiolane,98%;2-Iminothiolanehydrochloride,2-Thiolaniminehydrochloride,2IT,Dihydro-2(3H)-thiopheniminehydrochloride,Traut’sreagent;thiolan-Chemicalbook2-iMine;dihydrothiophen-2(3H)-iMine;2(3H)-ThiopheniMine,dihydro-,hydrochloride(1:1);2-Iminothiolanehydrochloride>=98%(TLC),powder;IMinothiolanehydrochlorid |
| CAS NO. | 4781-83-3 |
| Appearance | White solid |
| Purity | 98% |
| MF | C4H7NS.ClH |
| MW | 137.63 |
| Related categories | Pharmaceutical Intermediates |
| Storage | Keep in dark place,sealed in dry,room temperature |
| Transport Information | Class 6.1 dangerous goods |
| HS Code(in China) | 2934999099 |
| Contact information | Name:Echo Liu E-mail:echo@coreychem.com |
2-Iminothiolane Hydrochloride, commonly known as Traut’s Reagent, is a highly effective thiolation reagent widely used in biochemistry, biotechnology, pharmaceutical research, and protein engineering. The compound enables the introduction of sulfhydryl (-SH) groups into primary amine-containing biomolecules while preserving their biological activity.
Due to its mild reaction conditions and high selectivity, 2-Iminothiolane Hydrochloride has become an important tool for protein modification, antibody conjugation, enzyme immobilization, and the preparation of advanced bioconjugates.
2-Iminothiolane Hydrochloride is extensively used for the modification of proteins and peptides by converting amino groups into reactive sulfhydryl groups.
Typical applications include:
The reagent allows researchers to create reactive thiol-containing biomolecules for subsequent conjugation and labeling processes.
The introduction of sulfhydryl groups is a critical step in many bioconjugation strategies. 2-Iminothiolane Hydrochloride is widely employed in the preparation of antibody-drug conjugates and other targeted biological systems.
Applications include:
Its mild and efficient chemistry makes it highly suitable for sensitive biological materials.
In biotechnology laboratories, 2-Iminothiolane Hydrochloride is frequently used as a versatile reagent for creating functional biomolecules and studying biological interactions.
Research applications include:
The reagent provides researchers with a reliable method for introducing reactive thiol groups into biological systems.
2-Iminothiolane Hydrochloride is often utilized in combination with thiol-reactive crosslinkers to prepare stable conjugates and functionalized surfaces.
Common applications include:
These applications are increasingly important in medical diagnostics, bioanalytical technologies, and advanced biomedical research.
The compound plays a valuable role in pharmaceutical and diagnostic innovation by enabling the controlled modification of biomolecules used in therapeutic and analytical systems.
Applications include:
Its ability to selectively introduce thiol functionality supports the design of sophisticated biological products and research tools.
For samples, COA, pricing, or regulatory support, please contact:
Product Manager: Echo Liu
📧 Email: Echo@coreychem.com
📦 Packaging & Storage
Store in a tightly sealed container in a cool, dry, and well-ventilated area. Protect from moisture, excessive heat, and direct sunlight.
Proper storage helps maintain product quality and stability during transportation and long-term use.
Customized packaging options are available according to customer requirements for laboratory, pilot-scale, and commercial applications.
