2-Acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-D-glucopyranose (CAS: 50787-09-2) – Product Applications
2-Acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-D-glucopyranose, appearing as a white to off-white solid, is a natural endogenous metabolite and a specific acceptor substrate for α1,2-fucosyltransferase derived from Helicobacter pylori. With its unique sugar structure and biological activity, this product is mainly applied in the fields of glycobiology research, Helicobacter pylori-related research, biopharmaceutical R&D, and analytical testing. The specific applications are as follows:
I. Basic Glycobiology Research (Core Application Field)
As a disaccharide derivative containing acetamido, galactosyl and glucosyl groups, this compound is a key tool reagent for analyzing glycosylation modification mechanisms in glycobiology research. Its core applications include:
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Fucosyltransferase-related research: As a specific acceptor substrate for α1,2-fucosyltransferase fromHelicobacter pylori, it is used to in vitro verify the activity, catalytic efficiency and substrate specificity of this enzyme, clarify the glycosylation modification process mediated by fucosyltransferase, and provide core support for the functional research of fucosyltransferase.
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Sugar chain structure and function research: It is used to explore the structural characteristics of acetamido-containing disaccharides, as well as their physiological functions in cell signal transduction, cell adhesion and molecular recognition, helping to analyze the interaction mechanism between sugar chains and proteins or lipids.
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Endogenous metabolism research: As an endogenous metabolite, it can be used to track its metabolic pathway, distribution rule and metabolic regulation mechanism in organisms, providing a standard substrate for sugar metabolism-related research.
II. Helicobacter pylori-Related Research and Drug R&D
Infection with Helicobacter pylori is closely related to digestive system diseases such as gastritis, gastric ulcer and gastric cancer. Its α1,2-fucosyltransferase can catalyze the fucosylation modification of this compound, which in turn participates in the colonization and pathogenic process of Helicobacter pylori. Therefore, this product has important applications in the field of Helicobacter pylori research:
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Helicobacter pylori pathogenic mechanism research: It is used to simulate the in vivo environment, study the binding process between Helicobacter pylori and sugar chains on the host cell surface (with this compound as the core structure) through α1,2-fucosyltransferase, and clarify the colonization mechanism and pathogenic molecular pathway of Helicobacter pylori.
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Anti-Helicobacter pylori drug screening: As a specific substrate, it is used to establish a screening model for α1,2-fucosyltransferase inhibitors, screen potential drug molecules that can block the enzyme activity and inhibit Helicobacter pylori colonization, and provide tools for the R&D of new anti-Helicobacter pylori drugs.
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Diagnostic reagent R&D: It can be used as an antigen or probe to assist in the development of diagnostic reagents for Helicobacter pylori infection, used to detect the presence and activity of Helicobacter pylori in the body, and provide technical support for clinical diagnosis.
III. Biopharmaceutical and Vaccine R&D
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Vaccine adjuvant-related research: Its unique sugar structure can be used as a glycoantigen for the R&D of vaccines against Helicobacter pylori or glycosylation abnormality-related diseases, enhance the immunogenicity of vaccines, and assist in the development and optimization of vaccines.
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Glycodrug intermediate: As a disaccharide building block containing acetamido and galactosyl groups, it can be used to synthesize biologically active glycodrugs, antiviral drugs, anti-inflammatory drugs, etc., providing key intermediate support for biopharmaceutical R&D.
IV. Analytical Testing and Reference Standard Application
This compound has high purity and clear structure, and is an important standard reagent in the field of analytical testing. Its specific applications include:
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Reference standard: Used for the establishment, calibration and verification of analytical methods such as High Performance Liquid Chromatography (HPLC), Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) to ensure the accuracy and reliability of test results.
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Sample quantitative detection: As a reference substance, it is used for the quantitative analysis of this endogenous metabolite in biological samples (blood, tissue fluid, cell extracts), providing data support for the diagnosis and research of related diseases.
V. Other Potential Applications
In addition to the above core applications, this compound can also be used as an organic synthesis intermediate for the synthesis of fine chemicals and new sugar derivatives; at the same time, it has similar sugar structure fragments to Human Milk Oligosaccharides (HMOs), and can be used for the structural simulation and functional research of HMOs, providing reference for the R&D of infant formula food.
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