1,2,3,4-Tetrahydro-9-methylcarbazol-4-one; CAS: 27387-31-1

CAS NO.：27387-31-1

Purity: ≥99%
Appearance: White Needlelike crystalline powder
Product Manager Email: crystal@coreychem.com

Product Name:	1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
Synonyms:	1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONE;9-METHYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-4-ONE; Anthrdancione intermediate;Ondansetron EP Impurity C
CAS:	27387-31-1
MF:	C13H13NO
MW:	199.25
EINECS:	608-096-1
Product Categories:	Aromatics;Heterocycles;Impurities;Intermediates
Melting point	199.0 to 203.0 °C
Boiling point	383.5±11.0 °C(Predicted)
density	1.21±0.1 g/cm3(Predicted)
solubility	Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
Appearance	White Needlelike crystalline powder
HS code	2933990099
Transport Information	Non-hazardous goods

Frequently Asked Questions：
1. What is the main purpose of 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one?
This product serves as a key starting intermediate for ondansetron hydrochloride API. Ondansetron hydrochloride is a highly selective 5-HT₃ receptor antagonist clinically used for nausea and vomiting induced by chemotherapy, radiotherapy and surgery, and is a mainstream antiemetic drug.
2. What are the key physical or chemical properties?
This product features stable properties and low hygroscopicity. However, it is sensitive to strong light; prolonged exposure to light will cause yellow discoloration, which affects HPLC purity.
3. Annual production capacity, batch production capacity, purity standard?
This product meets a 99% purity specification with negligible batch-to-batch variation. Known and unknown impurities are under strict production control to satisfy pharmaceutical grade requirements. Ton-scale production is available, and we can arrange production promptly upon large orders.
4.What are the downstream products?
Mannich Intermediate
* 3-(Dimethylaminomethyl)-1,2,3,9-tetrahydro-9-methylcarbazol-4-one (CAS:153139-56-1) It is the Mannich reaction product of carbazolone, paraformaldehyde and dimethylamine hydrochloride. It is the most commonly used intermediate in domestic industrial processes, which undergoes amine exchange with 2-methylimidazole to yield ondansetron free base in the subsequent step.
* 1,2,3,9-Tetrahydro-9-methyl-3-methylenecarbazol-4-one (CAS:99614-64-9), a Mannich elimination product, also serves as an important intermediate / impurity in this synthetic route.
5. Appearance：

6. COA
Cas no 27387-31-1 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one COA

Application 1: What is the main use of this product in the pharmaceutical field?
Answer: It is a key starting intermediate for the synthesis of Ondansetron Hydrochloride API. Besides, it is used as Ondansetron EP Impurity C / USP Impurity C reference standard for related substance test and quality control of ondansetron.
Application 2: What role does it play in synthetic reactions?
Answer: It provides the tetrahydrocarbazolone parent core. It undergoes Mannich reaction to obtain Mannich intermediate, followed by amine exchange reaction and salt formation to construct the full molecular structure of Ondansetron Hydrochloride.
Application 3: Why does Ondansetron Hydrochloride synthesized from this product potentially have better pharmacological effects?
Answer: High purity of this starting material ensures low known/unknown impurities in downstream products, which reduces interfering substances and guarantees the quality and pharmacological activity of final Ondansetron Hydrochloride.

Packing size:
5kg/aluminium foil bag
25kg/Fiber can
Packing photo:

Storage temp：
Keep in dark place,Sealed in dry,Room Temperature
Expiration date：
About 36 months if properly stored