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White to yellow powder; Purity 99% MF: C20H16N2O5 MW: 364.35 A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy
Synonyms: Camptothecae Acuminatae extract;hydrate,(s)-dihydroxy;hydroxy-camptotheci;Hydroxycamptothencine;(20S)-10-HYDROXYCAMPTOTHECIN;(20S)-10-Hydroxycamptothecin;HYDROCAMPTOTHECINE;CAMPTOTHECIN, 10-HYDROXY(SH)
Product Categories: Inhibitors;natural product;Alkaloids;Natural Plant Extract;INTERMEDIATESOFIRINOTECANHCLTRIHYDRATE;Camptothecin series;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Natural Anti-cancer Medical Materials and It’s Derivatives
| Melting point | 265-270°C |
| Boiling point | 820.7±65.0 °C(Predicted) |
| density | 1.60 |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | ≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O |
| pka | 8.93±0.40(Predicted) |
| form | powder to crystal |
| color | White to Yellow to Orange |
| Purity | 99% |
| Product manager | Joy Wu; Email: Joy@coreychem.com |
A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy.DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways.
(S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.
CONTACT/Email address: Joy@coreychem.com
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