Sodium sulfobutylether β-cyclodextrin
Sodium sulfobutylether β-cyclodextrin
Sodium sulfobutylether β-cyclodextrin

Sodium sulfobutylether β-cyclodextrin

Model NO.
CoreyGC002
Delivery:
FOB
Minimum order quantity:
1 kilogram
Supply Ability:
1000 kilogram / Month
Country of Origin:
China
Stock Time:
3 Days
Quantity:
β-Cyclodextrin, sulfobutyl ethers, sodium salts Basic information
Product Name:    β-Cyclodextrin, sulfobutyl ethers, sodium salts
Synonyms:    CAPTISOL;Sodium sulfobutylether β-cyclodextrin;Betadex Sulfobutyl Ether Sodium (500 mg);sulfobutyl ether B-cyclodextrin;sodiuM salts;sulfobutyl ethers;SodiuM Sulphobutylether-β-Cyclodextrin;CAPTISOL,BETA-CYCLODEXTRIN SULFOBUTYL ETHERS, SODIUM SALT
CAS:    182410-00-0
MF:    C42H70O35
MW:    1134.9842
EINECS:    1308068-626-2
Product Categories:    -
Mol File:    182410-00-0.mol

β-Cyclodextrin, sulfobutyl ethers, sodium salts Chemical Properties
solubility     Soluble in water. Insoluble in acetone, methanol, chloroform.
form     Solid powder
color     White to off white
Safety Information
HS Code     2940006000
MSDS Information
Chemical Properties    β-Cyclodextrin, sulfobutyl ethers, sodium salts is White powder
Chemical Properties    β-Cyclodextrin, sulfobutyl ethers, sodium salts is a cyclic oligosaccharide containing seven D-(t)- glucopyranose units attached by α(1→4) glucoside bonds. Sulfobutylether b-cyclodextrin is an anionic bcyclodextrin derivative with a sodium sulfonate salt separated from the hydrophobic cavity by a butyl spacer group. The substituent is introduced at positions 2, 3, and 6 in at least one of the glucopyranose units in the cyclodextrin structure. Introducing the sulfobutylether (SBE) into b-cyclodextrin can produce materials with different degrees of substitution, theoretically from 1 to 21; the hepta-substituted preparation (SBE7-b-CD) is the cyclodextrin with the most desirable drug carrier properties. Sulfobutylether b-cyclodextrin occurs as a white amorphous powder.
Uses    β-Cyclodextrin, sulfobutyl ethers, sodium salts with sulfobutyl ether groups and sodium ions substituted along the length of the molecule. β-Cyclodextrin is a cyclic oligosaccharide produced from starch via enzymatic conversion. β-Cyclodextrin, sulfobutyl ethers, sodium salts is commonly used to produce HPLC columns allowing chiral enantiomers separation.
Uses    SBE- β –CD is a chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs.
Production Methods    Sulfobutylether β-cyclodextrin is prepared by alkylation of bcyclodextrin using 1,4-butane sultone under basic conditions. The degree of substitution in b-cyclodextrin is controlled by the stoichiometric ratio of β-cyclodextrin to sultone used in the process.
Pharmaceutical Applications    Cyclodextrins are crystalline, nonhygroscopic, cyclic oligosaccharides derived from starch (see Cyclodextrins). Sulfobutylether bcyclodextrin is an amorphous, anionic substituted b-cyclodextrin derivative; other substituted cyclodextrin derivatives are also available.
Sulfobutylether b-cyclodextrin can form noncovalent complexes with many types of compounds including small organic molecules, peptides, and proteins. It can also enhance their solubility and stability in water. The first application of sulfobutylether bcyclodextrin was in injectable preparations; it can also be used in oral solid and liquid dosage forms, and ophthalmic, inhalation, and intranasal formulations. Sulfobutylether bcyclodextrin can function as an osmotic agent and/or a solubilizer for controlled-release delivery, and has antimicrobial preservative properties when present at sufficient concentrations.

storage    Sulfobutylether b-cyclodextrin is stable in the solid state and should be protected from high humidity. It should be stored in a tightly sealed container in a cool, dry place.
 
  • CAS No.:182410-00-0
  • Other Names:CAPTISOL;Sodium sulfobutylether β-cyclodextrin;Betadex Sulfobutyl Ether Sodium (500 mg);sulfobutyl ether B-cyclodextrin;sodiuM salts;sulfobutyl ethers;SodiuM Sulphobutylether-β-Cyclodextrin;CAPTISOL,BETA-CYCLODEXTRIN SULFOBUTYL ETHERS, SODIUM SALT
  • MF:C42H70O35
  • EINECS No.:1308068-626-2
  • Place of Origin:China
  • Type:Pharmaceutical Intermediates
  • Purity:98%
  • Brand Name:Coreychem
  • Model Number:Grace002
  • Application:pharmaceutical excipients
  • Appearance:White powder
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