Product Manager: Selina Zhang; Email: Selina@coreychem.com
Product Name: 7-Azabenzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate
CAS No.: 156311-85-2
Main Uses / Functions
- Peptide Bond Formation (Primary Use)
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AOP is a highly efficient coupling reagent used to activate carboxylic acids or carboxyl groups, enabling their reaction with amines to form amide bonds (peptide bonds).
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It is widely used in both solution-phase and solid-phase peptide synthesis (SPPS).
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AOP serves as an alternative to common coupling reagents such as HATU, HBTU, and PyBOP, offering:
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High coupling efficiency
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Reduced racemization
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Cleaner reaction profiles
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Mechanistic note:
The “7-azabenzotriazole (HOAt)” moiety in AOP stabilizes reactive intermediates, improving reaction rate and yield.
2. Amide Bond Formation in General Organic Synthesis
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Beyond peptide chemistry, AOP can also be used to form amide bonds in small-molecule synthesis.
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It effectively promotes coupling between carboxylic acids and amines, or between compounds containing hydroxyl, amino, and carboxyl functional groups.
In summary:
AOP is a high-performance phosphonium-type coupling reagent widely used in peptide synthesis and amide bond formation. It offers excellent efficiency, low racemization, and is intended for research and laboratory use only.
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With our own laboratory and experienced R&D team, we specialize in custom synthesis and scale-up services, particularly in molecular building blocks, advanced pharmaceutical intermediates, and dye intermediates. We can develop tailor-made products based on your required chemical structure.
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Contact our product manager to get more information: selina@coreychem.com
