N,N’-Diisopropylcarbodiimide (CAS NO.: 693-13-0)：Efficient dehydrating condensing agent for peptide synthesis.
1、 Product Overview
N,N’-Diisopropylcarbodiimide is a highly efficient dehydrating condensing agent, widely used in peptide synthesis and pharmaceutical intermediate synthesis.
2、 Basic Product Information
1）Product Name: N,N’-Diisopropylcarbodiimide
2）CAS NO.：693-13-0
3）Molecular formula: C7H14N2
4）Molecular weight: 126.2
5）Structural formula:
6）Purity: ≥99%
7）Appearance: Condensing agent; organic chemical raw material
8）Boiling point: 145-148 °C
9）Transport Information: Class 6.1 dangerous goods
10）Product Manager Email:jessie@coreychem.com
3、 Frequently Asked Questions (FAQ)
Question 1:Please describe the basic physical characteristics of N,N’-Diisopropylcarbodiimide（CAS NO.: 693-13-0）.
N,N’-Diisopropylcarbodiimide is a colorless to light yellow transparent liquid at room temperature, with the molecular formula C₇H₁₄N₂ and a molecular weight of 126.20. Its density at 20°C is approximately 0.815 g/mL, and its boiling point range is 145-148°C. This product is miscible with common organic solvents such as ether, tetrahydrofuran, and dichloromethane, but insoluble in water.
Question 2:Key Application Features of This Product
The core use of this product is as a dehydrating condensing agent, activating carboxyl groups to promote the condensation of carboxylic acids with amines and efficiently form amides. Compared with DCC, DIC’s standout advantage is that it is liquid at room temperature, making measurement and transfer more convenient; meanwhile, its byproduct diisopropylurea (DIU) has higher solubility in organic solvents, simplifying post-reaction workup.
Question 3:Role of This Product in Pharmaceutical and Organic Synthesis Applications
In the pharmaceutical and organic synthesis fields, DIC is often used as a substitute for DCC in peptide synthesis. It can be used to prepare amides, anhydrides, aldehydes, ketones, isocyanates, and other compounds. It is also a key dehydrating reagent in the synthesis of drugs such as amikacin and glutathione, and is widely applied in fine chemicals.
Question 4:Storage and Handling of This Product
This product should be stored in a dry, cool, and well-ventilated area, with the container kept tightly closed and away from heat and ignition sources. Since DIC decomposes easily upon contact with water, storage under inert gas is recommended. Handling should be performed in a fume hood, wearing goggles, solvent-resistant gloves, and protective clothing, avoiding inhalation of vapors or direct contact with skin and eyes.
Question 5:Quality Control Specifications for N,N’-Diisopropylcarbodiimide
4、 Application Cases
Application 1:N,N’-Diisopropylcarbodiimide（CAS NO.: 693-13-0） in the Pharmaceutical Field
DIC is primarily used in the pharmaceutical field as a dehydrating condensing agent for the synthesis of peptide drugs and active pharmaceutical ingredients. Its mechanism of action involves activating carboxyl groups to promote the efficient condensation of carboxylic acids with amines to form amide bonds, making it a key reagent for constructing peptide chains and drug molecules. In the synthesis of drugs such as amikacin and glutathione, DIC serves as a dehydrating agent in key reaction steps. Compared with DCC, DIC’s byproduct diisopropylurea (DIU) is easier to remove, which helps improve drug purity, making it widely used in the pharmaceutical industry.
Application 2:The Role of N,N’-Diisopropylcarbodiimide in Peptide Synthesis
In peptide synthesis, DIC is typically used in combination with additives such as HOBt or Oxyma for carboxyl activation and amide bond formation. It effectively suppresses racemization during the reaction, improving peptide yield and optical purity. Since DIC is a liquid at room temperature, it is easy to measure accurately and handle in automated operations, making it particularly suitable for solid-phase peptide synthesis (SPPS) and large-scale liquid-phase peptide synthesis. It is an important alternative to DCC in peptide drug production.
Application 3:Applications of N,N’-Diisopropylcarbodiimide in Organic Synthesis
In organic synthesis, DIC is used not only for amide formation but also for preparing anhydrides, aldehydes, ketones, isocyanates, and other compounds. It can act as a carboxylic acid activator in esterification reactions and can also be used to synthesize reactive intermediates such as acylurea compounds. In addition, DIC is applied in heterocyclic compound synthesis and total synthesis of natural products, making it a commonly used condensing reagent in the fine chemical industry.
Application 4:The Role of N,N’-Diisopropylcarbodiimide in the Pesticide and Fine Chemical Fields
In the pesticide and fine chemical fields, DIC can be used to synthesize pesticide intermediates containing amide bonds. Many modern pesticide molecules (such as certain herbicides and insecticides) contain amide structures, and DIC can efficiently catalyze amide bond formation to help construct the target molecular skeleton. In addition, it is also used in the synthesis of intermediates for dyes, pigments, and various fine chemicals, demonstrating practical value in pesticide and fine chemical production.
Application 5:The Potential Applications of N,N’-Diisopropylcarbodiimide in the Field of Materials Science
In materials science, DIC can be used for the modification and functionalization of polymer materials. For example, it can activate carboxyl groups to graft functional molecules onto polymer chains, thereby imparting new properties such as hydrophilicity, biocompatibility, or specific recognition capability. In addition, DIC can also be used to synthesize polyamides, polyimides, and other polymer materials, showing potential applications in functional coatings, biomedical materials, and separation membranes.
5、 Safety and Storage
1）Store in a light-protected place (10-25°C).
2）Crystals may form during long-term storage; after filtration, the product remains usable.
6、Product Manager Information
Product Manager: Jessie Liu
Email: jessie@coreychem.com
