Pharmacopoeial Name: N-Hydroxysuccinimide
Chemical Name: N-HYDROXY-2,5-PYRROLIDINEDIONE
CAS No.: [6066-82-6]
- Description
N-Hydroxysuccinimide (NHS) is a white to off-white crystalline powder commonly used as a reagent in organic synthesis and biochemical research. It is widely known for its role in the formation of active esters that facilitate amide bond formation, especially in peptide synthesis and protein modification. - Product Specifications
Items
Standard
Appearance
White to off-white crystalline powder
Content, %
≥99
Melting point ( °C)
95~101
Moisture content, %
≤0.50
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Product Characteristics
Molecular Formula
C4H5NO3
Molecular Weight
115.09
Boiling Point
215.33°C (rough estimate)
Melting Point
95-98 °C(lit.)
Density
1.4769 (rough estimate)
Vapor Pressure
0Pa at 25℃
Stability
Stable. Incompatible with strong oxidants, acid chlorides, anhydrides, and strong bases. Moisture resistant.
Solubility
Store at +2°C to +8°C.
- Applications
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Used in the synthesis of NHS esters for peptide and protein labeling.
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Facilitates amide bond formation by activating carboxylic acids.
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Applied in bioconjugation reactions such as labeling of antibodies, proteins, and nucleic acids.
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Key intermediate in the development of crosslinking reagents and fluorescent dyes.
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Commonly used in solid-phase peptide synthesis (SPPS).
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- Packaging
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1g / 5g / 10g / 25g / 100g / 500g / 1kg in sealed HDPE or amber glass bottles.
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Custom packaging available upon request.
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Samples and further technical data can be provided upon request.
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