This product is a key advanced intermediate in the synthesis process of Dabrafenib. As an important BRAF kinase inhibitor, Dabrafenib is used to treat diseases such as BRAF V600 mutation-positive melanoma and non-small cell lung cancer. With its precise molecular structure, this intermediate directly determines the quality and efficacy of the final product, Dabrafenib, making it an indispensable core building block in the active pharmaceutical ingredient (API) synthesis route.
Product Basic Information
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Chemical Name: N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-diethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
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Synonym: Dabrafenib Intermediate 5
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CAS No.: 1195768-23-0
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Molecular Formula: C₂₃H₁₈ClF₃N₄O₂S₂
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Molecular Weight: 538.99
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Form: High-purity solid powder
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Purity: Routinely supplied at ≥98%
Main Application Fields
1. Dabrafenib API Process Development & Production
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Core Structural Unit: This product contains the characteristic thiazolopyrimidine skeleton and benzenesulfonamide structure present in the Dabrafenib molecule, serving as a key precursor for constructing the active pharmaceutical ingredient.
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Process Optimization: It can be used for the development of different synthetic routes, screening of process conditions, and scale-up studies.
2. Analog Research & New Drug Development
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Starting Point for Structural Modification: The chlorine atom, fluorine atoms, and pyrimidine ring in its molecule provide multiple reactive sites for further chemical modification, enabling the synthesis of Dabrafenib structural analogs.
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Kinase Inhibitor Development: As a versatile structural fragment for kinase inhibitor drugs, it can serve as a high-quality intermediate for the R&D of other targeted anti-tumor drugs.
Product Advantages
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Structural Precision: Strictly controlled synthesis processes ensure the molecular structure is completely consistent with design requirements, guaranteeing smooth downstream reactions.
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Consistent Quality: Mature production routes ensure highly consistent quality between batches, meeting the demands of continuous production.
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Reliable Supply: Capable of stable supply from gram to kilogram scale, supporting all customer stages from R&D to production.
To request samples or technical documentation, please contact:
Product Manager: Sophia
Email: sophia@coreychem.com
