Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate CAS No.: 205448-65-3

📌Specification:

Items	Specifications	Test Result
Appearance	Off white to brown powder	Complies
Identification	IR Confirm	Complies
Identification	The retention time of the main peak of the test solution should be consistent with that of the reference solution	Complies
Water content	≤1.0%	0.12%
Single Impurity	<0.5%	0.20%
Total impurity	≤2.0%	0.33%
Purity	≥99.0%	99.67%
Assay	97.0%~102.0% (on dry basis)	99.50%

🧩Application of Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate CAS No.: 205448-65-3

1. Pharmaceutical Industry (Primary Application)

Key pharmaceutical intermediate for the synthesis of anti-tumor small-molecule drugs

Featuring a characteristic quinolinone core, this compound serves as a vital intermediate in the manufacturing process of targeted anti-tumor drugs. It can be converted into key precursor materials of active pharmaceutical ingredients via multiple reactions including chlorination, substitution and amidation.
Pharmaceutical impurity reference standard

It can be used as impurity reference standard for pharmaceutical research and quality control.

Application scenarios:

Qualitative and quantitative HPLC analysis of active pharmaceutical ingredients;
Pharmaceutical process research, impurity tracing and production process optimization;
Development and verification of analytical methods during pharmaceutical research.

2. Building Block for New Drug R&D

The 4-oxo-1,4-dihydroquinoline heterocyclic skeleton is a favored structure for kinase inhibitors:

Synthesis of candidate compounds targeting various tyrosine kinases;
Screening of novel compounds with anti-tumor and anti-angiogenic activities;
Fundamental synthetic building block for new drug research in research institutes and CROs.

3. Fine Organic Synthesis

It is a multifunctional heterocyclic chemical containing methyl ester, alkoxy and quinolinone moieties.

Diversified derivatization reactions such as hydrolysis, halogenation, aminolysis and nucleophilic substitution can be carried out. It acts as raw material for synthesizing complex nitrogen-containing heterocyclic compounds.